SpringerLink

Incluye referencias bibliográficas e índice

Circulating tumor cells as cancer biomarkers in the clinic / Ludmilla Thomé Domingos Chinen, Emne Ali Abdallah, Alexcia Camila Braun [and others] -- Strategies for isolation and molecular profiling of circulating tumor cells / Jia-Yang Chen, Ying-Chih Chang -- Aptamer-based methods for detection of circulating tumor cells and their potential for personalized diagnostics / Anna S. Zamay, Galina S. Zamay, Olga S. Kolovskaya, Tatiana N. Zamay [and others] -- Development of a protocol for single-cell analysis of circulating tumor cells in patients with solid tumors / Carolina Reduzzi, Rosita Motta, Giulia Bertolini, Patrizia Miodini, Antonia Martinetti [and others] -- Flow cytometric methods for circulating tumor cell isolation and molecular analysis / Neha Bhagwat, Erica L. Carpenter -- Enrichment and detection of circulating tumor cells and other rare cell populations by microfluidic filtration / Michael Pugia, Mark Jesus M. Magbanua, John W. Park -- Detection and enumeration of circulating tumor cells with invasive phenotype / Haizhen Wang, Xiangwei Wu -- Molecular profiling and significance of circulating tumor cell based genetic signatures / Nisha Kanwar, Susan J. Done -- Detection of gene rearrangements in circulating tumor cells: examples of ALK-, ROS1-, RET-rearrangements in non-small-cell lung cancer and ERG-rearrangements in prostate cancer / Cyril Catelain, Emma Pailler, Marianne Oulhen, Vincent Faugeroux, Anne-Laure Pommier [and others] -- Enrichment, isolation and molecular characterization of EpCAM-negative circulating tumor cells / Rita Lampignano, Helen Schneck, Martin Neumann, Tanja Fehm, Hans Neubauer -- Expression of epithelial mesenchymal transition and cancer stem cell markers in circulating tumor cells / Stefan Werner, Arnulf Stenzl, Klaus Pantel, Tilman Todenh̲fer -- Mesenchymal-epithelial transition and circulating tumor cells in small cell lung cancer / Gerhard Hamilton, Barbara Rath -- Clinical relevance of a candidate stem cell marker, p75 neurotrophin receptor (p75NTR) expression in circulating tumor cells / Tomoyuki Okumura, Tetsuji Yamaguchi, Toru Watanabe, Takuya Nagata, Yutaka Shimada -- Personalized treatment through detection and monitoring of genetic aberrations in single circulating tumor cells / Swee Jin Tan, Trifanny Yeo, Sarvesh Abhay Sukhatme, Say Li Kong, Wan-Teck Lim [and others] -- Glycan markers as potential immunological targets in circulating tumor cells / Denong Wang, Lisa Wu, Xiaohe Liu -- Significance of EGFR expression in circulating tumor cells / María José Serrano, María Jesús Alvarez-Cubero, Diego De Miguel Pérez [and others].

"Numerous studies have shown that elevated levels of circulating tumor cells (CTCs) in blood of cancer patients are associated with poor response to treatment and inferior survival probabilities. Despite this clinical significance, the molecular biology of CTCs remains poorly understood. The paucity in molecular information can be attributed to the tremendous technical challenges involved in isolating these extremely rare cells. Recent technological advancements in rare-cell technology, however, have allowed for the reliable enrichment and isolation of CTCs. Consequently, the use of recently developed molecular approaches -e.g., multiplexed QPCR, microarray, and next generation sequencing analyses- to profile CTCs have provided novel insights into the molecular makeup of these tumor cells. This book discusses approaches for enrichment and isolation of CTCs as well as recent advances in comprehensive molecular profiling of CTCs using cutting-edge omics technology"--Publisher's description.