Incluye referencias bibliográficas e índice

Foreword; Preface; Contents; Contributors; Part I: Overview; Chapter 1: Epidemiology of Cancers in Sub-Saharan Africa; 1.1 Background; 1.2 Cancer Epidemiology in Sub-Saharan Africa; 1.2.1 Males; 1.2.2 Females; 1.3 Regional Variation in Cancer Epidemiology; 1.4 Risk Factors; 1.4.1 Virally-Mediated Cancers; 1.4.2 Lifestyle and Dietary Factors; 1.5 Challenges and Resources for Cancer Care; 1.5.1 Late Presentation; 1.5.2 Vaccinations; 1.5.3 Early Diagnosis; 1.5.4 Cancer Treatment; 1.5.5 Cultural Sensitivities; 1.5.6 Cancer Registries; 1.6 Cancer Projections; 1.7 Conclusion; References.

5.4 Importance of High Quality Cancer Related Research in SSA5.4.1 Current Status of Primary, Translational Research and Clinical Trials in Sub-Saharan Africa; 5.4.2 Challenges to Conducting Research in SSA; 5.5 Way Forward; 5.6 Controversies About North to South Health Related Research Collaboration in SSA; 5.7 Ethics and Research in SSA; 5.8 Conclusion; References; Part II: Site Specific Cancers; Chapter 6: Breast Cancer in Sub-Saharan Africa; 6.1 Introduction; 6.2 Epidemiology; 6.3 Risk Factors; 6.4 Clinical and Pathological Features; 6.5 Molecular Biology; 6.6 Diagnosis; 6.7 Treatment.

Chapter 2: Cancer Genomic and Epigenomic Variations in Sub-Saharan Africa2.1 Introduction; 2.1.1 Environmental Factors; 2.1.2 Mutational Signatures; 2.1.3 Global Molecular Pathways; 2.1.4 Genomic Research Output from Sub-Saharan Africa; 2.2 Global Genomic Differences; 2.2.1 Breast Cancer; 2.2.2 Colorectal Cancer; 2.2.3 Comments; 2.3 Single Nucleotide Polymorphism (SNP); 2.3.1 Prostate Cancer; 2.3.2 Race and Migration; 2.3.3 Variants in Infective Organisms; 2.4 Copy Number Variation (CNV); 2.5 Epigenetics; 2.5.1 Role of Infective Organisms; 2.5.2 Controversies; 2.6 Conclusion; References.

Chapter 3: Infection-Related Cancers in Sub-Saharan Africa3.1 Epidemiology; 3.2 Viruses; 3.2.1 Human Immunodeficiency Virus (HIV) and Cancers; 3.2.2 Human Papilloma Virus (HPV) and Cervical Cancer; 3.2.3 Hepatitis B Virus (HBV) and Hepatocellular Carcinoma; 3.2.4 Epstein-Barr Virus (EBV) and Related Malignancies; 3.2.5 Kaposi Sarcoma Herpes Virus (KSHV) and Kaposi Sarcoma (KS); 3.3 Non-viral Causes of Infection-Related Cancers; 3.4 Prevention; 3.4.1 Primary Prevention; 3.4.2 Secondary and Tertriary Prevention; 3.5 Conclusion; References.

Chapter 4: Pathological Services in Sub-Saharan Africa, a Barrier to Effective Cancer Care4.1 Introduction; 4.2 Pathology Tissue Handling and the Challenges Faced in the Various Sub-sections; 4.2.1 Histopathology/Surgical Samples; 4.2.2 Frozen Sections; 4.2.3 Cytopathology; 4.2.4 Immunohistochemistry and Molecular Diagnostics; 4.3 Cancer Registries; 4.4 Autopsy Services; 4.5 Conclusion; References; Chapter 5: Cancer: Primary, Translational Research and Clinical Trials in Sub-Saharan Africa; 5.1 Introduction; 5.2 Historical Perspectives; 5.3 Definition.

This book discusses the current state of cancer pathway as it is relevant to sub-Saharan Africa and highlights differences in epidemiology and the underlying problems with management. It outlines the current practice and opinions in all forms of cancer, also highlighting future prospects. Starting by providing background information on the epidemiology and genomic variations, the book then goes on to look at Infection-related cancers and continues to prostate GI, breast cancer and ovarian and cervical cancer. The last part of the book focuses on delivery of affordable and accessible care. Palliative services and primary and transnational research, as well as clinical trials are also discussed. Written by a team of authors based in the UK, Nigeria, South Africa and the US. this book offers an overview of the current state and challenges of cancer care in sub-Saharan Africa, and it would be valuable to policy makers, researchers, funding organisations, and can be an adjunct to standard text books for students, residents and established doctors.