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Series Preface; Preface; Contents; Contributors; Chapter 1: Cell Death in Drug-Induced Liver Injury; 1.1 Introduction; 1.2 Apoptosis in DILI; 1.2.1 FAS; 1.2.2 TRAIL; 1.2.3 Perforin/Granzyme; 1.2.4 TNF; 1.3 JNK in DILI; 1.4 Mitochondria in DILI; 1.5 ER Stress in DILI; 1.6 Regulated Necrosis DILI; 1.7 Autophagy in DILI; 1.8 Cell Death Biomarkers in DILI; 1.8.1 HMGB1; 1.8.2 Keratin 18 (K18); 1.8.3 miRNA; 1.9 Conclusion; References; Chapter 2: ER Stress in Drug-Induced Liver Injury; 2.1 Introduction; 2.2 ER Stress and the Unfolded Protein Response (UPR); 2.3 Drug-Induced Liver Injury (DILI).

2.4 HIV/AIDS and HIV PIs2.5 ER Stress and HIV PI-Induced Hepatotoxicity; 2.5.1 HIV PI-Induced Lipogenesis; 2.5.2 HIV PI-Induced Inflammation; 2.6 Summary; References; Chapter 3: Mechanisms of Acetaminophen-Induced Liver Injury; 3.1 Introduction; 3.2 Metabolism and Initiation of Toxicity; 3.3 The C-JUN-N-Terminal Kinase Pathway in APAP Toxicity; 3.4 The Role of the BCL-2 Protein Family in APAP Hepatotoxicity; 3.5 The Role of Receptor-Interacting Protein Kinase Family Members; 3.6 Oxidative and Nitrosative Stress in APAP Hepatotoxicity.

3.7 Mitochondria-Mediated DNA Fragmentation in APAP Toxicity3.8 Autophagy as an Adaptive Mechanism to APAP-Induced Cellular Stress; 3.9 The Sterile Inflammatory Response During APAP Hepatotoxicity; 3.10 Conclusions; References; Chapter 4: Cell Death and Liver Injuries in Hepatitis C Virus Infection; 4.1 Viral Hepatitis; 4.2 Hepatitis C Virus; 4.2.1 Hepatitis C Virus; 4.2.2 HCV Genome; 4.2.3 HCV Life Cycle; 4.3 Immune Evasion and Chronicity of HCV; 4.4 Cell Death and Liver Injury in Chronic HCV Infection; 4.4.1 Apoptosis: Implications in Inflammation.

4.4.2 Reactive Oxygen Species: Implications in Hepatic Cell Death and Tumorigenesis4.4.3 Autophagy: Implications in Cell Survival and Cancer; 4.4.4 Lipid Metabolism: Implications in Steatosis; 4.5 Conclusion and Future Perspective; References; Chapter 5: Hepatocyte Lethal and Nonlethal Lipotoxic Injury; 5.1 Introduction; 5.2 Lethal Hepatocyte Injury by Lipoapoptosis; 5.3 Lipoapoptosis and Liver Injury; 5.4 Nonlethal Hepatocyte Injury; 5.5 Conclusion; References; Chapter 6: Cell Death in Alcohol-Induced Liver Injury; 6.1 Introduction; 6.2 Alcohol Metabolism and Oxidative Stress.

6.3 Apoptosis, Necrosis, and Necroptosis in ALD6.4 Mechanisms of Alcohol-Induced Apoptosis in Hepatocytes; 6.5 Activation of Mitochondrial (Intrinsic) Apoptotic Pathway by Alcohol; 6.6 Activation of Death Receptor (Extrinsic) Apoptotic Pathway by Alcohol; 6.7 Necrosis and Necroptosis in ALD; 6.8 Other Forms of Regulated Programmed Cell Death in ALD; 6.8.1 Pyroptosis; 6.8.2 Ferroptosis; 6.9 Autophagy and Cell Death in ALD; 6.10 Concluding Remarks and Future Perspective; References; Chapter 7: Bile Acid-Induced Liver Injury in Cholestasis; 7.1 Introduction; 7.2 Bile Acid Biology.

This comprehensive volume describes drug and virus-mediated hepatocyte injury, alcohol, lipid and bile acid-induced hepatocyte injury in addition to ischemia-reperfusion-mediated liver injury. The chapter authors who discuss these topics are leading experts on cell death in liver diseases. The authors link these different types of liver injury to the commonly associated liver inflammation, fibrosis and tumorigenesis. Other topics explored include the various forms of cell death and cell survival pathways that have been identified in the liver, such as apoptosis, necroptosis, pryoptosis and autophagy. This book, along with its companion volume, Molecules, Systems and Signaling in Hepatic Cell Death, provides a thorough and comprehensive discussion on the topic of cell death and liver disease. Cellular Injury in Liver Diseases is an essential addition to the Cell Death in Biology and Diseases series and will appeal to scientists, clinicians and those doing research for drug discovery.