Incluye referencias bibliográficas e índice

Preface; Contents; Contributors; Ovarian Function; 1 Ovarian Endocrinology; Factors Regulate Ovarian Cycles; GnRH; Gonadotropins; Steroid Hormones; Sex Steroid Hormones; Glycoproteins; References; 2 Follicular Development and Oocyte Growth; Introduction; Follicular Development; From Primordial Follicles to Pre-antral Follicle; Formation of Primordial Follicles; Initial Recruitment of Follicles; Pre-antral Follicle Growth and Differentiation; From Antral to Pre-ovulatory Follicles; Antral Follicle Recruitment; Dominant Follicle Selection; Pre-ovulatory Follicle Development.

5 Natural Cycle IVF: Summary of the Current LiteratureIntroduction; Natural Cycle IVF; Low Responders; GnRH Antagonists; NSAID; Clomiphene Citrate; Mild Stimulation; In Vitro Maturation; Costs; Additional Aspects; Timing of Oocyte Retrieval; Analysis of Follicular Fluid; Summary; References; 6 Follicular Fluid Hormone Profiles in Natural Cycle IVF Patients During Follicular Phase; Introduction; Follicular Fluid Hormones in Folliculogenesis; Composition of Follicular Fluid; Ovary-Derived Hormones; Steroid Hormones; Oestrogens; Progestins; Androgens; Anti-Müllerian Hormone.

Oocyte-Derived Paracrine FactorsMeiotic Resumption; LH; Reduction of Intraoocyte cAMP Levels; Reduction of Intraoocyte cGMP Levels; Reduction of NPPC/NPR2 Function; EGF-Like Growth Factors; Calcium Signaling; Conclusion; References; 4 Mitochondria of the Oocyte; Introduction; Structural Property of Mitochondria in Mammalian Oocytes; Mechanism of Mitochondrial Traffic in Mammalian Oocytes; Energy Metabolism in Mammalian Oocytes; Genetic and Epigenetic Control of Mitochondria; Future Perspective; Conclusion; References; Natural Cycle IVF and Stimulated Cycle IVF.

Ovarian Follicular Wave DynamicsFollicle Atresia; Changes of Follicular Morphology and Metabolism During Atresia; Hormonal Regulation of Follicle Atresia; Molecular Mechanisms of Follicle Cell Apoptosis; Oocyte Growth; Size of Oocytes and Follicles; Mechanism of Oocyte Maturation; Nuclear Maturation; Cytoplasmic and Membrane Maturation; Epigenetic Modification; Conclusion; References; 3 A New Understanding on the Regulation of Oocyte Meiotic Prophase Arrest and Resumption; Meiotic Arrest; Oocyte Maturation Inhibitor; Cyclic Nucleotides; Cyclic AMP; Cyclic GMP; NPPC; FSH; Estrogen.

Pituitary-Derived HormonesFollicle-Stimulating Hormone; Luteinizing Hormone; Prolactin; Growth Hormone; Systemic Hormones; Insulin; Cortisol; Renin; Follicular Fluid Hormones in Natural Cycle IVF; Evidence for the Detrimental Impact of Exogenous Gonadotrophin Stimulation; Natural Cycle IVF; Follicular Fluid in Natural Cycles; Comparing Follicular Hormonal Milieu Between NC-IVF and COH-IVF Cycles; The Association Between FF Endocrine Profiles, Resultant Oocyte and Embryo Quality in NMC-IVF and COH-IVF; Pathology Related Follicular Hormone Profiles in NC-IVF; Weaknesses in Published Literature.

An ideal reference for infertility specialists and reproductive endocrinologists alike, this comprehensive text discusses current natural and mild approaches to in vitro fertilization (IVF) and the development of in vitro maturation (IVM) as a clinical treatment. It is divided thematically into four sections. Part I presents the basic science of ovarian endocrinology and the mechanism of oocyte maturation, including follicular development and the importance of mitochondrial changes. The differences between natural cycle IVF and stimulated IVF are presented in part II, including the standard ovarian stimulation protocols and their outcomes and the etiology, prevention and management of ovarian hyperstimulation syndrome (OHSS). Minimal and mild stimulation for IVF is discussed in part III, including mild stimulation protocols for oncofertility patients and the new minimally invasive INVO procedure. In vitro maturation as a clinical treatment is the subject of part IV, discussing the methodology of immature oocyte retrieval as well as other laboratory aspects and congenital and obstetrical outcomes of babies born from IVM. Combining expertise from thought leaders around the world, Development of In Vitro Maturation for Human Oocytes will be a go-to resource for infertility researchers and practitioners and reproductive endocrinologists working with infertile couples looking for safer and more cost-effective options for treatment.