SpringerLink Springer Biomedical and Life Sciences eBooks 2017 English+International

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Preface; Abstract; Contents; Part I: Evolution, Origin and Fate of Macrophages; Chapter 1: Evolutionary Aspects of Macrophages Polarization; 1.1 Introduction; 1.2 Macrophage Polarization in Mammals; 1.3 Evolutionary Conservation of M1/M2-Like Functional Heterogeneity; 1.3.1 Bony Fish; 1.3.2 Amphibians; 1.3.2.1 Macrophage Polarization During X. laevis Antiviral Responses; 1.3.2.2 Macrophage Polarization During X. laevis Antibacterial Responses; 1.4 Conclusion; References.

2.5 ConclusionsReferences; Chapter 3: Hofbauer Cells: Placental Macrophages of Fetal Origin; 3.1 Hofbauer Cell Definition and Origins; 3.2 The Biological Function of Hofbauer Cells; 3.3 Hofbauer Cells in Obstetric Complications; 3.4 Approaches for Studying Hofbauer Cells: Strengths and Potential Pitfalls; 3.5 Conclusions; References; Chapter 4: Mesenchymal Stem Cells Direct the Immunological Fate of Macrophages; 4.1 Introduction; 4.2 The Interplay Between Mesenchymal Stem Cells and Macrophages in Tissue Repair.

4.3 The Interplay Between Mesenchymal Stem Cells and Macrophages in Immune Tolerance4.4 Mesenchymal Stem Cells Promote Tumor Progression Through Macrophages; 4.5 Conclusions; References; Chapter 5: Monocyte/Macrophage: NK Cell Cooperation-Old Tools for New Functions; 5.1 Introduction; 5.2 Origin of Macrophages and NK Cells; 5.2.1 Macrophage Differentiation in Vertebrates and Invertebrates; 5.2.2 The Evolutionary Roots of Natural Killer Cells; 5.3 Phagocytosis; 5.3.1 Receptors Used in Phagocytosis; 5.4 Phenotypes of Vertebrate Macrophages; 5.4.1 Classification of Macrophages.

5.4.2 Plasticity and Polarization of Macrophages5.4.3 Polarization of Human Macrophages; 5.4.4 Molecular Mechanisms Underlying the Polarization of Macrophages; 5.5 Natural Killer Cells; 5.5.1 Definition and Classification; 5.5.2 Human NK Cell Population; 5.5.3 Origin and Development of NK Cells; 5.5.4 NK Licensing/Education Mechanisms; 5.5.5 Innate Memory NK Cells; 5.5.6 NK Cell Receptors; 5.5.6.1 Killer Cell Immunoglobulin-Like Receptors; 5.5.6.2 Natural Cytotoxicity Receptors; 5.5.6.3 C-Type Lectin-Like Receptors; 5.5.6.4 Fc Receptor CD16; 5.5.6.5 Co-activating Receptors.

Chapter 2: Development and Functional Differentiation of Tissue-Resident Versus Monocyte-Derived Macrophages in Inflammatory R ... 2.1 Introduction; 2.2 Heterogeneity of Circulating Monocytes and Tissue-Resident Macrophages; 2.3 Origin of Macrophages; 2.3.1 Monocytes and moMphi Development: Definitive/Adult Hematopoiesis; 2.3.2 trMphi Ontogeny: Primitive/Fetal Hematopoiesis; 2.4 trMphi Versus moMphi; 2.4.1 In Situ Macrophage Expansion/Proliferation Versus Monocyte Recruitment; 2.4.2 Are moMphi and trMphi Phenotypically Distinguishable?; 2.4.3 Are moMphi and trMphi Functionally Interchangeable?

This volume gives a state-of-the-art overview on macrophage functions in various invertebrate and vertebrate systems and diseases. It also covers various aspects of macrophage development and formation, behavior and response to nano- and biomaterials, the latter of which have become very important components of modern medicine. Macrophages are evolutionarily conserved phagocytotic cells. In recent years macrophages have emerged as one of the most versatile cells of immune system, which, depending on the milieu and circumstance, participate in development or inhibition of cancer, regeneration, wound healing, inflammation, organ rejection and interaction between mother and a fetus. This book will be of particular interest to researchers working in immunology, cancer research, developmental biology, or related fields.