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Incluye referencias bibliográficas e índice

Introduction to sigma receptors: their role in disease and as therapeutic targets / Sylvia B. Smith -- Structural perspectives on sigma-1 receptor function / Assaf Alon, Hayden Schmidt, Sanduo Zheng, Andrew C. Kruse -- A review of the human sigma-1 receptor structure / Felipe Ossa, Jason R. Schnell, José Luis Ortega-Roldan -- Fluorinated pet tracers for molecular imaging of [sigma]1 receptors in the central nervous system / Frauke Weber, Peter Brust, Erik Laurini, Sabrina Pricl, Bernhard Wünsch -- The evolution of the sigma-2 ([sigma2) receptor from obscure binding site to bona fide therapeutic target / Chenbo Zeng, Robert H. Mach -- Sigma 1 receptor and ion channel dynamics in cancer / Olivier Soriani, Rapha͡l Rapetti-Mauss -- Sigma-1 receptors fine-tune the neuronal networks / Shang-Yi Anne Tsai, Tsung-Ping Su -- Pharmacological modulation of the sigma 1 receptor and the treatment of pain / Manuel Merlos, Javier Burgueño, Enrique Portillo-Salido, Carlos Ramón Plata-Salamán [and others] -- Sigma-1 receptor antagonists: a new class of neuromodulatory analgesics / Cristina Sánchez-Fernández, José Manuel Entrena, José Manuel Baeyens [and others] -- Sigma-1 receptors and neurodegenerative diseases: towards a hypothesis of sigma-1 receptors as amplifiers of neurodegeneration and neuroprotection / Linda Nguyen, Brandon P. Lucke-Wold, Shona Mookerjee, Nidhi Kaushal, Rae R. Matsumoto -- Sigma-1 receptor agonists and their clinical implications in neuropsychiatric disorders / Yakup Albayrak, Kenji Hashimoto -- Role of sigma-1 receptor in cocaine abuse and neurodegenerative disease / Yu Cai, Lu Yang, Fang Niu, Ke Liao, Shilpa Buch -- Sigma receptors and substance use disorders / Valentina Sabino, Callum Hicks, Pietro Cottone -- Stimulation of the sigma-1 receptor and the effects on neurogenesis and depressive behaviors in mice / Kohji Fukunaga, Shigeki Moriguchi -- Role of [sigma]1 receptors in learning and memory and Alzheimer's disease-type dementia / Tangui Maurice, Nino Goguadze -- Sigma-1 receptor in motoneuron disease / Renzo Mancuso, Xavier Navarro -- The sigma-1 receptor-A therapeutic target for the treatment of ALS? / Timur A. Mavlyutov, Erin M. Baker, Tasher M. Losenegger, Jaimie R. Kim, Brian Torres [and others] -- The role of sigma1R in mammalian retina / Jing Wang, Xuezhi Cui, Penny Roon, Alan Saul, Sylvia B. Smith -- Peeking into sigma-1 receptor functions through the retina / Timur A. Mavlyutov, Lian-Wang Guo -- The role of sigma 1 receptor as a neuroprotective target in glaucoma / Barbara Mysona, Neil Kansara, Jing Zhao, Kathryn Bollinger.

"Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It's putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Huntington's disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein"--Publisher's description.