SpringerLink

Incluye referencias bibliográficas e índice

Molecular biology of aquaporins / Chunling Li, Weidong Wang -- The evolutionary aspects of aquaporin family / Kenichi Ishibashi, Yoshiyuki Morishita, Yasuko Tanaka -- Transport characteristics of aquaporins / Xiaoqiang Geng, Baoxue Yang -- Aquaporins and gland secretion / Christine Delporte -- Aquaporins in nervous system / Mengmeng Xu, Ming Xiao, Shao Li, Baoxue Yang -- Aquaporins in cardiovascular system / Lu Tie, Di Wang, Yundi Shi, Xuejun Li -- Aquaporins in respiratory system / Yuanlin Song, Linlin Wang, Jian Wang, Chunxue Bai -- Aquaporins in digestive system / Shuai Zhu Bachelor, Jianhua Ran, Baoxue Yang, Zhechuan Mei -- Aquaporins in urinary system / Yingjie Li, Weiling Wang, Tao Jiang, Baoxue Yang -- The physiological role and regulation of aquaporins in teleost germ cells / Joan Cerdà, Fraṅçois Chauvigné, Roderick Nigel Finn -- Aquaporins in the skin / Ravi Patel, L. Kevin Heard, Xunsheng Chen, Wendy B. Bollag -- Aquaporins in the eye / Thuy Linh Tran, Steffen Hamann, Steffen Heegaard -- Aquaporins in fetal development / Nora Martínez, Alicia E. Damiano -- Diabetes insipidus / H.A. Jenny Lu -- Aquaporins in obesity / Inês Vieira da Silva, Graça Soveral -- Aquaporin-targeted therapeutics: state-of-the-field / Lukmanee Tradtrantip, Bjung-Ju Jin, Xiaoming Yao [and others] -- Water transport mediated by other membrane proteins / Boyue Huang, Hongkai Wang, Baoxue Yang -- Methods to measure water permeability / Evgeniy I. Solenov, Galina S. Baturina, Liubov E. Katkova [and others].

This book provides a state-of-the-art report on our current understanding of aquaporins and the future direction of the field. Aquaporins (AQPs) are a group of water-channel proteins that are specifically permeable to water and other small molecules, such as glycerol and urea. To date thirteen water-channel proteins (AQP0 ℓ́ℓ AQP12) have been cloned and the mechanisms and physiological functions of water transport across biological membranes have long been the subject of interest. Recent advances in the molecular biology and physiology of water transport have yielded new insights into how and why water moves across cell membranes, and studies on aquaporin knockout mouse models suggest that aquaporins are involved in the development of some diseases and they may be useful targets of research into selective-inhibitor drugs. By focusing on the advances made over the last 20 years in the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of aquaporins in mammalian cell membranes, this book provides novel insights into further mechanisms and the physiological significance of water and some small molecule transport in mammals in order to stimulate further research in new directions.