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Preface; Contents; Contributors; Part I: Updates on Salivary Gland Development; 1: Implications of Salivary Gland Developmental Mechanisms for the Regeneration of Adult Damaged Tissues; 1.1 Introduction; 1.2 Epithelial Growth Driven by Stem Cells; 1.2.1 Morphological Development of Salivary Glands; 1.2.2 Contribution of Stem Cells and Their Differentiating Progeny; 1.2.3 Lessons from Developmental Regulatory Mechanisms Guiding the Epithelium; 1.3 Environmental Cues Patterning Epithelial Branching and Maturation; 1.3.1 Guiding Neurons; 1.3.2 The Role of Blood Vessels.

1.3.3 Supporting Mesenchymal Cells1.4 Translation into Future Therapies to Repair Damaged Salivary Glands; 1.4.1 Epithelial Protection and Repair; 1.4.2 Inducing Neuronal Survival and Reinnervation; 1.4.3 Restoration of Blood Vessel Supply; 1.4.4 Inflammation and Stromal Cell-Induced Fibrosis; 1.5 Future Prospects; References; 2: Systems Biology: Salivary Gland Development, Disease, and Regenerative Medicine; 2.1 Introduction; 2.2 Current Reductionist Approaches to Understand Salivary Gland Development; 2.2.1 Organ Explants, Organoid Culture, and Other Primary Cultures.

2.2.2 Transgenic Mouse Models2.3 Systems-Based Approaches to the Study of Gland Development; 2.3.1 Salivary Gland Molecular Anatomy Project; 2.3.2 Comparison of the transcriptome of embryonic salivary glands grown in vivo as compared with that of embryonic organ explants grown ex vivo; 2.3.3 Systems-Level Analysis to Identify Temporal-Spatial Differences in Gene Expression During Salivary Gland Development; 2.3.4 Systems-Level Analysis of Salivary Gland Differentiation Networks; 2.4 Systems Approaches to the Study of Salivary Gland Disease; 2.4.1 Systems-Based Analysis of Saliva.

2.4.2 Systems-Based Methods to Diagnose Salivary Gland Diseases: Sjögren's Syndrome2.4.3 Sjogren's Syndrome Disease Progression; 2.4.4 Systems Approaches to Understand Radiation Sensitivity of Salivary Glands Following Radiation Treatment for Head and Neck Cancers; 2.4.5 Systems Approaches to Characterize Salivary Gland Tumors; 2.5 Systems Analysis and Regenerative Therapies; 2.5.1 Systems Analysis in Characterizing Cell Populations; 2.6 Conclusions and Outlook; References; 3: Mucins in Salivary Gland Development, Regeneration, and Disease.

3.1 Structure, Biosynthesis and Functions of Salivary Mucins3.2 Expression of Mucins During Salivary Gland Development; 3.3 Mucin and the Regeneration of Salivary Glands; 3.3.1 Regeneration of Salivary Glands Damaged by Radiation; 3.3.2 Bioengineered Germ Transplants for Salivary Gland Regeneration; 3.3.3 Regeneration of Salivary Glands Atrophied by Ligation; 3.4 Mucins and Sjögren's Syndrome; 3.4.1 Factors Related to the Secretory Activity of Salivary Glands of SS Patients; 3.4.2 Mucins in SS Patients; 3.4.3 Evaluation of the Sulfo-Lewisa Biosynthesis Pathway.

This book provides a comprehensive update on the latest information and knowledge which emerged from translational and basic science research endeavors, targeting the regeneration of salivary glands. The coverage includes salivary gland growth and development, stem cell therapy, bioengineering of salivary glands, and perspectives on and practical approaches to restoration of secretory function. More specifically, among the individual topics addressed are the various types of stem cell of value for cell replacement therapy, technological advances with respect to 3D printing, gene therapy, organ culture of salivary glands, and surgical aspects of the feasibility and practicality of transplantation. Readers will find helpful practical guidance on functional restorations of damaged salivary glands and stimulating insights into potential future directions in salivary gland regeneration research. The authors are all acknowledged experts from a range of academic and clinical backgrounds. Accordingly, the book will be of interest not only to clinicians, such as general dental practitioners, oral medicine specialists, and surgeons who manage dry mouth patients, but also to biomedical engineers, stem cell researchers, and transplant surgeons.

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