Foreword; Contents; 1: Confocal Laser Endomicroscopy in GI Tract; 1.1 Introduction; 1.2 Physics; 1.3 Systems; 1.4 Gastrointestinal Applications; 1.4.1 Barrett's Esophagus (BE); 1.4.2 Gastritis and Early Gastric Cancer; 1.4.3 Celiac Disease; 1.4.4 Inflammatory Bowel Disease; 1.4.5 Polyps; 1.4.6 Pancreas; 1.4.7 Biliary Tract; 1.4.8 Primary Sclerosing Cholangitis (PSC); 1.4.9 Solid Organs; References; 2: OTSC System in All Possible Applications; 2.1 Introduction; 2.2 Technical Concepts; 2.3 OTSC in GI Bleeding; 2.4 The New Device DC ClipCutter.

2.5 Performance of Over-The-Scope Clip System in the Endoscopic Closure of Iatrogenic Gastrointestinal Perforations and Postsurgical Leaks2.6 Perforation; 2.7 Postsurgical Leaks; 2.8 Gastrointestinal Fistulas; 2.9 Over-The-Scope Clip Full-Thickness Resection Device (OTSC FTRD); References; 3: Radiofrequency Ablation of Pancreatic Mass; 3.1 Introduction; 3.2 Radiofrequency Ablation and Pancreatic Carcinoma; 3.2.1 Operative Technique; 3.3 The Pilot Study; 3.4 Single-Center Overall Experience; 3.4.1 Complications; 3.5 Immunomodulatory Effects of RFA.

3.6 Control of an Aggressive Disease3.6.1 Imaging and Pathology After RFA; 3.7 Timing of the Procedure; 3.8 Clinical Trials; 3.9 Endoscopic Ultrasound-Guided Ablation; References; 4: TEM and TAMIS for Large Rectal Neoplasm; 4.1 Introduction; 4.1.1 Pit Pattern Classification; 4.1.2 Endoscopic Ultrasound (EUS); 4.1.3 Biopsy; 4.1.4 Lifting Sign; 4.1.5 Digital Examination; 4.2 Technique; 4.2.1 Equipment; 4.2.2 Positioning of the Patient on the Operating Table; 4.2.3 Surgical Technique; 4.2.3.1 Step 1: Dissection; 4.2.3.2 Step 2: Wall Defect Suturing.

4.2.4 Postoperative Management4.3 TEM Versus ESD; 4.4 TAMIS; 4.5 Extended Indications; 4.6 Future Perspectives; References; 5: Unusual Applications of Metal Stents in Gastrointestinal Tract; 5.1 Introduction; 5.2 Unusual Application of Stents in Upper GI Tract; 5.2.1 Upper Malignant Esophageal Strictures; 5.2.2 Benign Esophageal Strictures; 5.2.3 Benign Esophageal Leakages or Fistula; 5.2.4 Variceal Bleeding; 5.2.5 Esophageal Achalasia; 5.2.6 Staple Line Leaks Postlaparoscopic Sleeve Gastrectomy; 5.3 Unusual Application of Stents in Low GI Tract.

5.3.1 Self-Expanding Metallic Stents for Malignant Obstruction5.3.2 Colonic SEMS as a Bridge to Surgery; 5.3.3 Colonic SEMS as Palliative Therapy; 5.3.4 SEMS in Benign Colorectal Diseases; References; 6: Endoscopic Suturing Systems; References; 7: Endoluminal Therapy for Treatment of Gastroesophageal Reflux Disease; 7.1 Introduction; 7.2 Endoluminal Techniques; 7.2.1 Implantations and Injections; 7.2.2 Radiofrequency Ablation; 7.2.3 Endoscopic Tissue Apposition Techniques; 7.3 Techniques for Transoral Incisionless Fundoplication; 7.3.1 Pre-procedure Evaluation.

In this book, leading international experts describe and discuss the various techniques available for the screening, diagnosis, management, and follow-up of digestive diseases, providing clinically useful, up-to-date reviews that draw upon their own experience and focus attention on the most recent advances in the field. Among the wide range of topics covered are the use of confocal laser endomicroscopy in the gastrointestinal tract, endoscopic suture systems, endoscopic submucosal dissection, per oral endoscopic myotomy, and cholangioscopy systems. The experience of a leading surgical group in the application of endoscopic radiofrequency ablation in pancreatic cancer is reported, and new surgical and endoscopic techniques for the treatment of Zenker's diverticulum are proposed. The closing chapters examine the present and future of esophageal motility testing and the diagnostic yield of novel parameters in reflux monitoring. In addition to the discussion of techniques, advice is provided on training, endoscopy and imaging equipment, and set-up of endoscopy units during procedures.