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Dedication; Foreword; Foreword; Introduction; Contents; Contributors; Chapter 1: Epidemiology of€Childhood Cancer in Africa; Case Presentation; Geographical Variations; Acute Leukemias; Lymphomas; Central Nervous System Tumors; Neuroblastomas; Retinoblastomas; Kidney Tumors; Liver Tumors; Osteosarcoma; Ewing Sarcoma; Mesenchymal tumors; Germ Cell Tumors; Thyroïd Carcinomas; Nasopharyngeal Carcinomas; Environmental or Iatrogenic Risk Factors; Ionizing Radiation; Chemotherapy; Electromagnetic Fields; Chemical Exposures; Parental Smoking; Parental Alcoholism; Birth Weight.

Breast Feeding Hair Dye; In Vitro Fertilization; Infection; Genetic Risk Factors; Down Syndrome; Li-Fraumeni Syndrome; Ataxia Telangiectasia; Hereditary Retinoblastoma; Fanconi Anemia; Syndrome of€Rhabdoid Predisposition; Xeroderma Pigmentosum Syndrome; Phacomatosis; Nephroblastoma and€Anomalies of€the€WT1 Gene; Key Points and€Practical Recommendations; Suggested Reading; Chapter 2: Early Warning Signs and€Diagnostic Approach in€Childhood Cancer; Case Presentation; Diagnostic Delay in€Childhood Cancer; Early Warning Signs of€Childhood Cancer.

Chapter 4: Organization of Care for Children with Cancer in Africa Prerequisite to Put in Place Pediatric Oncology Unit; Human Resources; Required Hospital Environment; Functional Organization of Cancer Care; Integration to Regional, National, or International Programs; Parent Associations; Health Care Team and Burnout; Practical Recommendations in Limited Resource Settings; Suggested Selective Reading; Chapter 5: Hematological and€Oncological Emergencies; Definition; Respiratory Emergencies; Case Presentation 1; Findings on€Examination; Superior Vena Cava Syndrome.

Children with€a€High Risk of€Cancer Clinical Diagnosis of€Childhood Cancers; Diagnostic Procedures; Abdominal Mass; Intra-Thoracic Masses; Intracranial Masses; Lymphadenopathy; Soft Tissue Masses; Bone Pain; Summary; Suggested Reading; Chapter 3: Cancer Registries and€the€Value of€a€Dedicated Pediatric Registry in€Africa; So, What Is a€Cancer Registry?; Types of€Registries; What Is the€Value of€a€Cancer Registry?; International and€African Organization of€Support of€Cancer Registration; Classification of€Childhood Cancer; Take Home Messages; Suggested Reading.

Clinical Presentation Diagnosis; Management; Treatment; Case Presentation 2; Findings on€Examination; Pericardial Effusion/Cardiac Tamponade; Cardiac Tamponade; Clinical Presentation; Diagnosis; Treatment; Case Presentation 3; Findings on€Examination; Malignant Pleural Effusion; Clinical Presentation; Diagnosis; Treatment; Case Presentation 4; Findings on€Examination; Central Airway Compression Syndrome; Clinical Presentation; Treatment; Neurological Emergency; Case Presentation; Findings on€Examination; Spinal Cord Compression; Clinical Presentation.

This text is the only book of its kind to provide specific guidance applicable to limited resource settings and builds up from the foundation of general practitioner or general pediatrician competence. Written and edited by leaders in the field, this manual educates physicians on the essential components of the discipline, filtered through the experience of specialists from developing countries, with immediate applicability in the specific healthcare environment in these countries. Typically, manuals of pediatric hematology-oncology are written by specialists from high-income countries, and usually target an audience with a sub-specialist level of training, often assisted by cutting-edge diagnostic and treatment facilities. However, approximately 80% of new cases of cancer in children appear in mid- and low-income countries. Almost invariably, general practitioners or general pediatricians without special training in oncology will look after children with malignancies who enter the health care system in these countries. The diagnostic facilities are usually limited, as are the treatment options. The survival figures in these conditions are somewhere below 20%, while in high-income countries they are in the range of 80% for many childhood cancers. This book includes simplified therapy protocols, pain therapy and palliation, as well as ward procedures such as bone marrow aspiration/biopsies, intravenous therapy and chemotherapy drugs mixing. It provides an overview of pediatric cancer epidemiology, cancer registration and organizing support networks and features the management of cancers with associated pathology like AIDS, malnutrition, malaria and tuberculosis.