Preface; Contents; Contributors; Chapter 1: Fertility Risk with Cancer Therapy; Introduction; Estimating Risk; Males; Females; Minimizing Risk; Gonadotropin-Releasing Hormone Agonist; Imatinib; Bone Marrow-Derived Mesenchymal Stem Cells; Sphingosine-1-phosphate (S1P); Tamoxifen; AS101; Granulocyte Colony-Stimulating Factor (G-CSF); Conclusion; References; Chapter 2: Fertility Preservation Options for Female Pediatric and Adolescent Oncology Patients; Introduction; Protection of Ovarian Function; Ovarian Transposition; Ovarian Suppression; Assisted Reproductive Endocrinology.

Combined Hormonal Contraception (Pill, Patch, Ring) Levonorgestrel IUD for Menstrual Suppression; Appendix: Medical Eligibility Criteria for Contraceptive Use; References; Chapter 5: Female Sexual Function in Childhood, Adolescent, and Young Adult Cancer Survivors; Scope of the Problem; Barriers to Care; Sexual Development; Infancy and Childhood; Preadolescence; Adolescence; Sexual Development in Survivors of Childhood Cancer; Risk Factors for Sexual Dysfunction; Long-Term and Late Effects of Cancer Treatment on Sexual Functioning; Physiologic Effects; Psychosocial Effects.

Embryo and Oocyte Cryopreservation Ovarian Tissue Cryopreservation and Transplantation; Assessment of Ovarian Reserve; Reproductive Options Post Therapy; Donor Oocytes and Embryos; Fertility Preservation Post Therapy; Gestational Carrier; Adoption; Access to Fertility Preservation; Ethical Considerations; Future Directions; Generation of Gametes from Somatic Cells; Coverage of Fertility Preservation by Insurance; Conclusion; References; Chapter 3: Assessing Ovarian Reserve; Background; Assessing Ovarian Reserve; Menstrual Cycles; Antral Follicle Counts and Ovarian Volume.

Endocrine Hormones Follicle-Stimulating Hormone (FSH), Inhibin B, and Estradiol; Anti-Mullerian Hormone (AMH); Current Data on AMH in Children Receiving Cancer Therapy; Ovarian Reserve Testing as a Predictor of Menstrual Pattern and Fertility; Effect of Female Hormones on Ovarian Reserve Testing; References; Chapter 4: Contraception and Menstrual Suppression for Adolescent and Young Adult Oncology Patients; Contraception; Survivors; Menstrual Regulation and Suppression; GnRH Agonist; Progestin-Only Pills; Depot Medroxyprogesterone Acetate.

Social Effects Female Sexual Dysfunction; Female Sexual Interest/Arousal Disorder (FSIAD); Female Orgasmic Disorder; Genito-pelvic Pain/Penetration Disorder (GPPPD); Screening and Assessment; Treatment; Education and Setting of Expectations; Non-pharmacologic Therapies; Pharmacologic Therapies; When to Refer; Conclusion; References; Chapter 6: Vitrification of Ovarian Tissue for Fertility Preservation; Introduction; Vitrification: Facts and Fallacies; Development of Ovarian Tissue Vitrification Based on Cryobiological Principles; Endpoints of Vitrification Success.

Reflecting the increasing interest in fertility management for pediatric and adolescent patients and fulfilling an urgent need to have a comprehensive guide to the management of these individuals, this is the first book of its kind to present a comprehensive discussion of pediatric and adolescent oncofertility. It carefully examines the impact of pediatric cancer and cancer therapy on fertility and presents both current and emerging fertility preservation techniques for both males and females, such as cryopreservation. Fertility concerns beyond cancer are also discussed, including disorders of sexual differentiation, gender dysphoria and thalassemia. Practical chapters on pediatric oncofertility in the clinic round out the book, covering setting up a practice, counseling and consent, disclosure and insurance considerations. Concluding chapters document fertility preservation techniques and outcomes internationally, with contributions from Portuguese, Brazilian and Japanese authors. Timely and wide-ranging, Pediatric and Adolescent Oncofertility is an ideal resource for reproductive medicine specialists, pediatric oncologists, and primary care physicians treating pediatric and adolescent cancer patients looking to protect fertility options.