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Bone marrow stem cell therapy for stroke / Kunlin Jin, Xunming Ji, Qichuan Zhuge, editors.

Contributor(s): Ji, Xunming,, editor literario | Jin, Kunlin,, editor literario | Zhuge, Qichuan,, editor literario
Material type: materialTypeLabelE-bookPublisher: Singapore : Springer, 2017Description: 1 recurso en línea.ISBN: 9789811029295; 9811029296.Subject: Células madreOnline resources: Acceso a este recurso digital (usuarios Universidad Europea de Madrid)Digital Resources
Contents:
Dedication; Preface; Contents; Contributors; Chapter 1: Ischemic Stroke Pathophysiology and Cell Therapy; 1.1 Introduction; 1.2 Pathophysiology of Ischemic Stroke; 1.2.1 Thrombosis; 1.2.2 Embolism; 1.2.3 Systemic Hypoperfusion; 1.2.4 Cellular Pathophysiology; 1.2.5 Cell Death After Stroke; 1.2.6 Mechanisms of Necrotic Cell Death; 1.2.7 Mechanisms of Programmed Cell Death; 1.3 Types of Stem Cells Used in Experimental Ischemic Stroke Therapy; 1.3.1 Embryonic Stem Cells (ESCs); 1.3.2 Mesenchymal Stem Cells (MSCs); 1.3.3 Bone Marrow-Derived MSCs (BMSCs).
1.3.4 Adipose-Derived Mesenchymal Stem Cells (AD-MSCs)1.3.5 Placenta-Derived Mesenchymal Stem Cells (PD-MSCs); 1.3.6 Induced Pluripotent Stem Cells (iPSCs); 1.3.6.1 Cell Therapy Using iPSCs for Stroke; 1.3.6.2 Mechanism of iPSC Therapy in Stroke; 1.3.7 Endothelial Progenitor Cells (EPCs); 1.3.7.1 Mechanism of EPC Therapy in Stroke; 1.3.8 Neural Stem Cells; 1.3.8.1 The Attempts to Treat Stroke with NSCs; 1.3.8.2 Underlying Mechanisms; References; Chapter 2: Bone Marrow Stem Cells: Source, Characterization, Isolation, Culture, and Identification; 2.1 Introduction; 2.2 Source.
2.2.1 Mesenchymal Stem Cells2.2.2 Hematopoietic Stem Cells; 2.2.3 Endothelial Progenitor Cells; 2.3 Characterization and Identification; 2.3.1 MSCs; 2.3.1.1 Morphology and Cell Cycle Study; 2.3.1.2 Differentiation Capacity; 2.3.1.3 Function; 2.3.1.4 Phenotype and Identification; 2.3.2 HSCs; 2.3.2.1 Multipotency; 2.3.2.2 Self-Renewal; 2.3.2.3 Markers and Identification; 2.3.3 EPCs; 2.3.3.1 Regenerative Potential of EPCs; 2.3.3.2 Phenotype and Identification; 2.4 Isolation; 2.4.1 MSCs; 2.4.2 HSCs; 2.4.3 EPCs; 2.5 Culture; 2.5.1 MSCs; 2.5.2 EPCs; 2.6 Conclusion; References.
3.3.2.1 Mechanisms of HSPC Mobilization After Stroke3.3.2.1.1 The SDF-1/CXCR4 Interaction; 3.3.2.1.2 Interplays of the Sympathetic Nervous System with SDF-1/CXCR4 and G-CSF; 3.3.2.2 Agents That Enhance the Mobilization of HSCs for Stroke; 3.3.3 HSC Homing to the Ischemic Brain; 3.3.3.1 Mechanisms of HSC Homing After Stroke; 3.3.3.2 Methods of Enhancing HSC Homing to Ischemic Brain; 3.3.4 Regulations of HSC on Neural Restoration and Neural Function After Stroke; 3.4 Bone Marrow-Derived Endothelial Progenitor Cells; 3.4.1 Characteristics of EPCs; 3.4.1.1 EPCs and Angiogenesis.
Chapter 3: Mobilization and Homing of Bone Marrow Stem Cells After Stroke3.1 Introduction; 3.2 Bone Mesenchymal Stem Cells; 3.2.1 The Characterization of BMSCs; 3.2.2 BMSC Mobilization After Stroke; 3.2.3 The Potential Signaling Pathway/Mechanisms Underlying BMSC Homing; 3.2.3.1 MCP-1; 3.2.3.2 CD44 and Selectin; 3.2.4 BMSCs Induced Neurotrophic Factor Secretion and Restoration of Neural Function; 3.3 Bone Marrow-Derived Hematopoietic Stem Cells; 3.3.1 The Characterization of HSCs and the Niches; 3.3.1.1 The Characterization of HSCs; 3.3.1.2 The HSC Niches; 3.3.2 HSC Mobilization After Stroke.
Abstract: This book covers recent advances in all aspects of bone marrow-derived stem cells (BMSCs) for stroke treatment, while also providing comprehensive information on human clinical trials and animal models of stroke. In addition, it reviews the optimal conditions of transplantation for stroke therapy and potential mechanisms underlying transplanted cell-mediated functional recovery after stroke. As the first book to focus on BMSC therapy for stroke, it also discusses in depth the unique challenges of BMSCs-based therapy in this context.
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Holdings
Item type Current library Collection Call number Status Date due Barcode Item holds
LIBRO-E NO PRÉSTAMO LIBRO-E NO PRÉSTAMO Madrid Digital Acceso Electrónico (UEM) Ciencias e Ingeniería QH588.S83 B664 2017 EB (Browse shelf(Opens below)) Acceso electrónico eBook.20022650
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Dedication; Preface; Contents; Contributors; Chapter 1: Ischemic Stroke Pathophysiology and Cell Therapy; 1.1 Introduction; 1.2 Pathophysiology of Ischemic Stroke; 1.2.1 Thrombosis; 1.2.2 Embolism; 1.2.3 Systemic Hypoperfusion; 1.2.4 Cellular Pathophysiology; 1.2.5 Cell Death After Stroke; 1.2.6 Mechanisms of Necrotic Cell Death; 1.2.7 Mechanisms of Programmed Cell Death; 1.3 Types of Stem Cells Used in Experimental Ischemic Stroke Therapy; 1.3.1 Embryonic Stem Cells (ESCs); 1.3.2 Mesenchymal Stem Cells (MSCs); 1.3.3 Bone Marrow-Derived MSCs (BMSCs).

1.3.4 Adipose-Derived Mesenchymal Stem Cells (AD-MSCs)1.3.5 Placenta-Derived Mesenchymal Stem Cells (PD-MSCs); 1.3.6 Induced Pluripotent Stem Cells (iPSCs); 1.3.6.1 Cell Therapy Using iPSCs for Stroke; 1.3.6.2 Mechanism of iPSC Therapy in Stroke; 1.3.7 Endothelial Progenitor Cells (EPCs); 1.3.7.1 Mechanism of EPC Therapy in Stroke; 1.3.8 Neural Stem Cells; 1.3.8.1 The Attempts to Treat Stroke with NSCs; 1.3.8.2 Underlying Mechanisms; References; Chapter 2: Bone Marrow Stem Cells: Source, Characterization, Isolation, Culture, and Identification; 2.1 Introduction; 2.2 Source.

2.2.1 Mesenchymal Stem Cells2.2.2 Hematopoietic Stem Cells; 2.2.3 Endothelial Progenitor Cells; 2.3 Characterization and Identification; 2.3.1 MSCs; 2.3.1.1 Morphology and Cell Cycle Study; 2.3.1.2 Differentiation Capacity; 2.3.1.3 Function; 2.3.1.4 Phenotype and Identification; 2.3.2 HSCs; 2.3.2.1 Multipotency; 2.3.2.2 Self-Renewal; 2.3.2.3 Markers and Identification; 2.3.3 EPCs; 2.3.3.1 Regenerative Potential of EPCs; 2.3.3.2 Phenotype and Identification; 2.4 Isolation; 2.4.1 MSCs; 2.4.2 HSCs; 2.4.3 EPCs; 2.5 Culture; 2.5.1 MSCs; 2.5.2 EPCs; 2.6 Conclusion; References.

3.3.2.1 Mechanisms of HSPC Mobilization After Stroke3.3.2.1.1 The SDF-1/CXCR4 Interaction; 3.3.2.1.2 Interplays of the Sympathetic Nervous System with SDF-1/CXCR4 and G-CSF; 3.3.2.2 Agents That Enhance the Mobilization of HSCs for Stroke; 3.3.3 HSC Homing to the Ischemic Brain; 3.3.3.1 Mechanisms of HSC Homing After Stroke; 3.3.3.2 Methods of Enhancing HSC Homing to Ischemic Brain; 3.3.4 Regulations of HSC on Neural Restoration and Neural Function After Stroke; 3.4 Bone Marrow-Derived Endothelial Progenitor Cells; 3.4.1 Characteristics of EPCs; 3.4.1.1 EPCs and Angiogenesis.

Chapter 3: Mobilization and Homing of Bone Marrow Stem Cells After Stroke3.1 Introduction; 3.2 Bone Mesenchymal Stem Cells; 3.2.1 The Characterization of BMSCs; 3.2.2 BMSC Mobilization After Stroke; 3.2.3 The Potential Signaling Pathway/Mechanisms Underlying BMSC Homing; 3.2.3.1 MCP-1; 3.2.3.2 CD44 and Selectin; 3.2.4 BMSCs Induced Neurotrophic Factor Secretion and Restoration of Neural Function; 3.3 Bone Marrow-Derived Hematopoietic Stem Cells; 3.3.1 The Characterization of HSCs and the Niches; 3.3.1.1 The Characterization of HSCs; 3.3.1.2 The HSC Niches; 3.3.2 HSC Mobilization After Stroke.

This book covers recent advances in all aspects of bone marrow-derived stem cells (BMSCs) for stroke treatment, while also providing comprehensive information on human clinical trials and animal models of stroke. In addition, it reviews the optimal conditions of transplantation for stroke therapy and potential mechanisms underlying transplanted cell-mediated functional recovery after stroke. As the first book to focus on BMSC therapy for stroke, it also discusses in depth the unique challenges of BMSCs-based therapy in this context.

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