Introduction; Contents; Contributors; 1: Dealing with€the€Gross Specimen; Introduction; Core Biopsies; Dealing with€Specimens from€Conservative Surgery; Reporting Excision Margin Status; Lumpectomy Specimens; Mastectomy Specimens; Axillary Lymph Node Specimens and€Specimens Received After€Neoadjuvant Therapy; References; 2: Handling Neoadjuvant Therapy Specimens; Introduction; Pretreatment Diagnosis; Specimen Handling; Wide Local Excision Specimens; Mastectomies; Axillary Lymph Nodes; Histological Reporting; Breast; Axillary Lymph Nodes; Definition of€pCR.

Flat Epithelial AtypiaReferences; 4: Problematic Core Biopsies; Introduction; Macroscopic Specimen Handling; Calcification Problems; Reporting Categories; B1, Normal Tissue; B2, Benign; B5, Malignant; Category B5a: In€Situ Carcinoma; Category B5b: Invasive; Assessment of€Prognostic and€Predictive Factors in€Invasive Carcinoma in€Core Biopsy; Problematic Malignant Lesions; B3, Lesion of€Uncertain Malignant Potential; Atypical Intraductal Epithelial Proliferations (AIDEPs); Lobular Neoplasia; Flat Epithelial Atypia; Apocrine Lesions; Papillary Lesions.

Grading of€Response Retesting of€Tumor Markers Post-Ưneoadjuvant Therapy; Neoadjuvant Therapy and€Clinical Trials; References; 3: Proliferative Breast Lesions; Introduction; Ductal Lesions; Usual Epithelial Hyperplasia; Atypical Ductal Hyperplasia; Ductal Carcinoma In€Situ; Epithelial Proliferation (Hyperplasia, Atypia, and€DCIS) Within€Papillary Lesions; Paget's Disease of€the€Nipple; Lobular Lesions; Atypical Lobular Hyperplasia and€Classical Lobular Carcinoma In€Situ (In Situ Lobular Neoplasia); Columnar Cell Lesions; Columnar Cell Change and€Columnar Cell Hyperplasia.

Radial Scar/Complex Sclerosing Lesion (CSL) Phyllodes Tumor; Spindle Cell Lesions; Mucocele-Like Lesions; Other Rare Lesions; B4, Suspicious; References; 5: Ductal Carcinoma In€Situ; Introduction; Specimen Handling; Diagnostic Core Biopsies; Diagnostic and€Therapeutic Excision Specimens; Re-excision Specimens; Therapeutic Mammoplasties; Mastectomy Specimens; Disease Extent in€Excision Specimens; Diagnostic Approaches with€Core Biopsies and€Excisions; Reporting Diagnostic Core Biopsies (Small and€Large Volume); Reporting Therapeutic Large Core (Vacuum-Assisted) Biopsies.

Reporting Excision Biopsies Grading DCIS; Low-Grade DCIS; Intermediate-Grade DCIS; High-Grade DCIS; Problems in€Grading DCIS; Architectural Patterns and€"Special" Types of€DCIS; Micropapillary DCIS; Apocrine DCIS; DCIS Arising in€the€Context of€a€Columnar Cell Lesion with€Atypia; Rare Forms of€DCIS; DCIS Following€Neoadjuvant Systemic Therapy; Microinvasion and€Invasion in€DCIS; The Use of€Immunohistochemistry in€DCIS; Differentiating Low/Intermediate-ƯGrade DCIS from€Benign Proliferations; Distinguishing Complex Sclerosing Processes from€Invasive Disease.

This book covers practical diagnostic issues in breast pathology, with special emphasis on areas which pose diagnostic difficulties. These include dealing with the gross specimens derived from patients treated with conservative surgery and those who had neo-adjuvant therapy before surgery. It also discusses how to deal with axillary lymph nodes, proliferative breast lesions, including DCIS, and problematic core biopsies, as well as fibro-epithelial, spindle cell, lobular, mucinous, metaplastic and papillary lesions, molecular classification of breast cancers, breast lesions in male patients and breast immunohistochemistry. There is a focus on unusual benign and malignant breast lesions and a large number of high-quality images help the reader diagnose difficult cases. Breast Pathology: Problematic Issues is aimed at histopathology consultants and senior trainees who deal with breast pathology.