Foreword; Foreword; Foreword; Foreword; Preface; The Evolution of Adolescent Oncology in the United States; Background; A Decade of Experience: 1978-1989; Scaling Up: 1992-The Present; References; Contents; 1: Adolescent and Young Adult Oncology: Historical and Global Perspectives; References; 2: Cancer Incidence, Survival, and Mortality Among Adolescents and Young Adults; 2.1 Introduction; 2.2 Sources of Information and Modes of Analysis: Incidence, Survival, and Mortality; 2.2.1 Age; 2.3 Data Sources and Analyses; 2.3.1 Incidence; 2.3.2 Survival; 2.3.3 Mortality.

2.4 Global, Regional, and National Perspectives; 2.4.1 Incidence; 2.4.1.1 Cancer Incidence Worldwide; 2.4.1.2 Worldwide Geographic Variation; 2.4.1.3 Overall Incidence by Single Years of Age (US SEER); 2.4.1.4 Individual Cancer Incidence by 5-Year Age Intervals (US SEER); 2.4.1.5 Individual Cancer Incidence by Age Group, Site, and Sex (US SEER); 2.4.1.6 Incidence Trends by Site (US SEER); 2.4.2 Survival; 2.4.2.1 Site Distribution and Survival (Europe, US SEER, Japan); 2.4.2.2 Survival for AYAs Compared to Children (Age <15 Years).

2.4.2.3 Survival for AYAs Compared to Older Adults (Age 40-69); 2.4.2.4 Survival Trends; 2.4.3 Mortality; 2.4.3.1 Cancer Mortality Worldwide; 2.4.3.2 Death Rates and Trends by Site; 2.5 Etiology, Biology, Trends, and International Progress; Appendix; References; 3: The Biology of AYA Cancers; 3.1 Introduction; 3.2 Old Questions and New Technologies; 3.3 Four AYA Cancers with Biologic Distinction; 3.3.1 Colorectal Cancer; 3.3.2 Acute Lymphoblastic Leukemia; 3.3.3 Breast Cancer; 3.3.4 Melanoma; 3.3.5 Sarcoma; 3.4 Summary; References; 4: Non-Hodgkin Lymphoma; 4.1 Introduction.

4.2 Epidemiology; 4.2.1 Age-Specific Incidence; 4.2.2 Incidence of Histologic Types; 4.3 Etiology/Risk Factors; 4.4 Histology/Cytogenetics; 4.5 Clinical Features; 4.6 Initial Workup and Staging; 4.7 B-Cell Non-Hodgkin Lymphoma; 4.7.1 Burkitt Lymphoma; 4.7.2 Diffuse Large B-Cell Lymphoma; 4.7.2.1 Primary Mediastinal B-Cell Lymphoma; 4.7.3 Anaplastic Large Cell Lymphoma; 4.7.3.1 Biology/Pathology; 4.7.3.2 Management of S-ALCL; 4.7.3.3 Management of C-ALCL; 4.7.3.4 Prognostic Factors; 4.7.3.5 Treatment of Relapses; 4.8 Lymphoblastic Lymphoma; 4.8.1 Biology/Pathology.

4.8.2 Treatment and Management; 4.9 Rare Non-Hodgkin Lymphomas in Adolescents and Young Adults; 4.10 Overall Survival; References; 5: Hodgkin Lymphoma; 5.1 Introduction; 5.2 Epidemiology; 5.2.1 Incidence; 5.2.1.1 Age and Gender; 5.2.1.2 Race and Ethnicity; 5.3 Etiology and Pathogenesis; 5.4 Pathology; 5.5 Presenting Features; 5.6 Diagnostic Testing; 5.6.1 Tissue Diagnosis; 5.6.2 Other Laboratory Studies; 5.6.3 Imaging Studies; 5.7 Staging and Risk Assessment; 5.7.1 Risk Strata for Treatment Determination; 5.8 Therapy; 5.8.1 General Principles.

5.8.2 Management of Limited-Stage Hodgkin Lymphoma.

This is the second edition of the only book to be devoted exclusively to the total cancer picture in adolescents and young adults (AYA), now expanded from the age range 15-29 to that of 15-39 years. For each of the diverse spectrum of cancers encountered in the AYA group, the epidemiology, natural progression, diagnostic approaches, and treatment options are described, with special emphasis on strategies for early detection and prevention. Comparison is made with management of both younger and older patients, and model programs are presented that address common diagnostic, staging, treatment, and psychosocial shortcomings in the AYA group. Detailed attention is also paid to principles and practices of care, with consideration of psychosocial and quality of life issues, social support systems, rehabilitation, late effects, insurance, and economic aspects of health care, among other topics. The authors make compelling arguments for integrated strategies that allow young adults to benefit from the combined expertise of pediatric and adult oncologists in systems that identify both the complex disease and the social issues specific to this population. The proposed models of care include relationships with other specialties that do not specifically target this age group, i.e., infectious disease, endocrinology, pulmonary medicine, nephrology, gastroenterology, thoracic and abdominal surgery, urology, otolaryngology, and neurosurgery. New patterns of communication are advocated and endorsed as essential for productive interaction involving these specialties. References are extensive and are oriented toward users in pediatric hematology-oncology medical oncology, radiation oncology, surgical oncology, gynecologic oncology, oncology nursing, psycho-oncology, social work, epidemiology, public health and health services research. The contributing authors are from the United States, the United Kingdom, Canada, Italy, France, Israel, Switzerland and Australia, Germany, Japan and the Netherlands.