Preface; Contents; Contributors; Chapter 1: Adipocytes, Adipocytokines, and€Cancer; Adipose Tissue; Adipocytokines and€Cancer; Leptin; Adiponectin; Visfatin; Resistin; Apelin; Chemerin; Omentin; Nesfatin; Vaspin; Retinol-Binding Protein-4; Cytokines; Adipocytes and Tumor Metabolism; Conclusion; References; Chapter 2: Adiponectin, Obesity, and€Cancer; Introduction; Adiponectin; Adiponectin Isoforms: Structural Considerations; Adiponectin Receptors; Adiponectin Modifications: Implication for€Cancer; Adiponectin Signaling Pathways Related to€Cancer.

Activation of€Adiponectin as€an€Indirect Strategy to€Inhibit Leptin Conclusion; References; Chapter 5: Retinol Binding Protein 4: Role in€Diabetes and€Cancer; Vitamin A: Absorption and€Metabolism; Retinoid-Binding Proteins; RBP4 and€Transport of€Retinol in€the€Circulation; Cellular Retinol-Binding Proteins; Vitamin A Uptake by Extrahepatic Tissues: RBP4 and€STRA6; RBP4 Level Is Correlated with€Obesity and€Insulin Resistance; RBP4 and€STRA6 in€Insulin Resistance: A€Mechanism of€Action; Alternative Models for€Understanding How RBP4 Induces Insulin Resistance.

Connection Between Dysregulated Leptin Levels and€Cancer Effect of€Leptin on€Cancer Progression and€Metastasis; Leptin as€a€Regulator or an€Important Participant of€Various Oncogenic Pathways; Canonical Signaling Pathways of€Leptin; Noncanonical Signaling-Functional Interactions of€Leptin with€Multiple Pathways; Leptin, Estrogen, and€Aromatase; Leptin, IGF1, Insulin, and€EGFR; Leptin, Notch, and€Wnt/Catenin Pathway; Strategies to€Inhibit Leptin Signaling; Direct Inhibition of€Leptin Signaling Using Small Molecule Inhibitors.

Preclinical Rodent Studies Evaluating Leptin's Effects on€Mammary Tumor Development/Progression Leptin/Adiponectin Ratio; Leptin Antagonists; Leptin Advances Malignancy in€Tumor Cells via€Additional Intrinsic Mechanisms; Leptin Effects on€the€Tumor Microenvironment also Contributes to€Tumor Progression; Leptin's Role in€Inflammation, Chemotaxis, and€Adaptive Immunity Impacts the€Cancer Host's Immune Responses; Leptin and Non-breast Malignancies; Conclusions; References; Chapter 4: Leptin-Signaling Pathways as€Therapeutic Targets in€Cancer.

Role of€Adiponectin in Tumor Initiation and€Progression Types of€Cancer Associated with€Obesity and€Decreased Adiponectin; Colorectal Cancer; Endometrial Cancer; Prostate Cancer; Breast Cancer; Gastric Cancer; Hematological Malignancies; The L/A Ratio; Adiponectin Chemopreventatives; Concluding Remarks; References; Chapter 3: Leptin in€Cancer: Epidemiology and Mechanisms; An Overview of€the€Early Studies of€Leptin and Breast Cancer; Epidemiological Studies of€Leptin and€Breast Cancer; Recent In Vitro Studies.