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Sirtuins / edited by Riekelt H. Houtkooper

Contributor(s): Houtkooper, Riekelt H., editor literario
Material type: materialTypeLabelE-bookSeries: Proteins and Cell Regulation; 1010Publisher: Dordrecht : Springer, 2016Description: 1 recurso en línea (VIII, 288 p.) : 30 ilustraciones, 24 ilustraciones en color.ISBN: 9789402409628.Subject: Proteínas | Química bioorgánica | Metabolismo -- TrastornosOnline resources: Click here to access onlineDigital Resources
Contents:
General introduction, Riekelt H. Houtkooper -- Biochemistry and Enzymology of Sirtuins, Yue Yang and Anthony A. Sauve -- NAD+ as a pharmacological tool to boost sirtuin activity, Riekelt H. Houtkooper -- Protein lysine acylation: abundance, dynamics and function, Olga Pougovkina and Vincent C. J. de Boer -- SIRT1 in metabolic health and disease, Marie Boutant and Carles Cantó -- Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function, Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey -- SIRT5 reveals novel enzymatic activities of sirtuins, Bin He and Hening Lin -- Diverse roles for SIRT6 in mammalian healthspan and longevity, Bernadette M. M. Zwaans, William Giblin and David B. Lombard -- Sirtuins in cancer \2013 emerging role as modulators of metabolic reprogramming, Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis -- Sirtuins as metabolic modulators of muscle plasticity, Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx -- Sirtuins and aging, Carles Cantó and Riekelt Houtkooper -- Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk, Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi -- Sirtuin activation by small molecules, Hassina Massudi, Lindsay E. Wu, and David A. Sinclair -- Future perspective, Brian Kennedy -- Index
Summary: The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease
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Holdings
Item type Current library Collection Call number Copy number Status Date due Barcode Item holds
LIBRO-E NO PRÉSTAMO LIBRO-E NO PRÉSTAMO Madrid Digital Acceso Electrónico (UEM) Ciencias de la Salud QP551 .S57 2016 EB (Browse shelf(Opens below)) .i11604785 Acceso electrónico eBOOK .i11604785
Total holds: 0

General introduction, Riekelt H. Houtkooper -- Biochemistry and Enzymology of Sirtuins, Yue Yang and Anthony A. Sauve -- NAD+ as a pharmacological tool to boost sirtuin activity, Riekelt H. Houtkooper -- Protein lysine acylation: abundance, dynamics and function, Olga Pougovkina and Vincent C. J. de Boer -- SIRT1 in metabolic health and disease, Marie Boutant and Carles Cantó -- Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function, Peter Chhoy, Kristin A. Anderson, Kathleen A. Hershberger, Frank K. Huynh, Angelical S. Martin, Eoin McDonnell, Brett S. Peterson, Laura A. Starzenski, Donald S. Backos, Kristofer S. Fritz, and Matthew D. Hirschey -- SIRT5 reveals novel enzymatic activities of sirtuins, Bin He and Hening Lin -- Diverse roles for SIRT6 in mammalian healthspan and longevity, Bernadette M. M. Zwaans, William Giblin and David B. Lombard -- Sirtuins in cancer \2013 emerging role as modulators of metabolic reprogramming, Jaewon J. Lee, Karina N. Gonzalez Herrera and Marcia C. Haigis -- Sirtuins as metabolic modulators of muscle plasticity, Keir Menzies, Julien Francisco Zaldivar-Jolissaint and Johan Auwerx -- Sirtuins and aging, Carles Cantó and Riekelt Houtkooper -- Sirtuins and the Circadian Clock: Epigenetic and Metabolic Crosstalk, Selma Masri, Marina Maria Bellet and Paolo Sassone-Corsi -- Sirtuin activation by small molecules, Hassina Massudi, Lindsay E. Wu, and David A. Sinclair -- Future perspective, Brian Kennedy -- Index

The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease

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