Particle Therapy in the Third Millennium Current Status and Future Outlook -- Development of Cyclotrons for Proton and Particle Therapy -- Development of C-ion Radiotherapy Technologies in Japan -- Physical rationale for protontherapy and elements to build a clinical center -- Radiation Dosimetry of Proton Beams -- Clinical pencil beam scanning: present and future practices -- Treatment planning for protons � An essay.-�Radiation Therapy with Protons and Heavy Ions -- Robustness Quantification and Worst-Case Robust Optimization in Intensity-Modulated Proton Therapy -- Modeling of Biological Effect of Charged Particles for C-Ion RT -- SFUD, IMPT and plan robustness.

The results of decades of research and development are providing compelling evidence about the efficacy of radiation therapy with proton and carbon ion beams to achieve superior complication free tumor control leading to a world-wide rapid growth in their clinical use. This book contains comprehensive reviews of the state of the art of the technology and physics of heavy charge particle therapy by the experts from the leading cancer centers of world that will be valuable as a practical guide for radiation therapy professionals interested in these modalities.