1. Introduction -- 2. Defining the problem of high-risk SCC: Epidemiology and Outcomes of SCC/Scope of The Problem -- 3. The Evidence For Clinical and Histologic Risk Predictors -- 4. Tumor Staging Systems and Prognostic Stratification -- 5. The scienceof SCC: Molecular/Genetic Underpinnings of Tumorormation/Progression/Metastasis/Immunosurveillance -- 6. Management: Management of Patients With Multiple Sccs/Field Cancerization -- 7. Management of High-Risk Primary Tumors -- 8. Management of Extensive Local Recurrence/In-Transit Metastasis -- 9. Management of Nodal Metastases -- 10. Management of Widely Metastatic and Unresectable Disease.

This book is a cutting-edge resource that provides clinicians with the up-to-date practical knowledge required in order to manage SCC patients optimally. It summarizes newly available information relating to the definition of high-risk SCC, its pathophysiologic underpinnings, and its management. New prognostic information and staging systems are summarized that enable high-risk tumors to be defined more precisely than ever before. Many helpful tips are provided on the practical management of challenging cases, including multiple tumors/field cancerization, high-risk tumors, nodal metastases, and unresectable disease. The authors are all acknowledged experts in the emerging field of high-risk and advanced SCC.