Basics of bone biology -- Towards the automated detection and characterization of osteoclasts in microscopic images -- An introduction to the immune system -- Effects of vitamin D in the immune system -- Osteoimmunological aspects of biomechanics -- Utility of the determination of biomarkers of bone metabolism -- Osteoporosis: Pathophysiology and clinical aspects -- Rheumatoid arthritis and ankylosing spondylitis -- RANKL inhibition: preclinical data -- RANKL inhibition: clinical data -- Osteoimmunological aspects of periodontal diseases -- Transplantation immunology.

This fully updated and extended second edition provides a comprehensive overview on the basic concepts of the rapidly developing field of osteoimmunology and also offers in-depth insights into the molecular mechanisms of bone diseases. Clinical data is presented and put into context with the latest research findings. This second edition in addition discusses the latest topics in transplantation immunology. The book addresses scientists and physicians working in immunology, pathophysiology and osteology.