PART I CURRENT HEART FAILURE THERAPIES 1 Therapies in heart failure, tomorrow may be too late -- 2 �Atrial fibrillation, heart failure and the autonomic nervous system -- 3 Current therapies for ventricular tachycardia. Are there autonomic implications of the arrhythmogenic substrate? -- PART II THE AUTONOMIC REGULATION AND DIS-REGULATION OF THE HEART: PATHOPHYSIOLOGY IN HEART FAILURE�4 zThe autonomic Nervous system symphony orchestray: Pathophysiology of Autonomic Nervous system and Analysis of Activity Frequences.-�5 Autonomic pathophysiology after myocardial infarction falling into heart failure.-�6 Cardiovascular serenade: listening to the heart.-�7 Whispering during sleep: autonomic signalling during sleep, sleep apnoea and sudden death.-�8 Cerebral aging: Implications for the autonomic nervous system regulation -- PART III MODULATION OF AUTONOMIC FUNCTION IN HEART FAILURE�9 The autonomic cardiorenal cross-talk: pathophysiology and implications for heart failure management.-�10 Vagal Stimulation in Heart failure: an antiinflammatory intervention? -- 11 Baroreflex activation therapy in heart failure -- 12 Renal reflexes and denervation in heart failure -- 13 Conclusions: back to the future.

This book describes the most recent insights into heart failure and the role played by autonomic nervous system pathophysiology in it, discussing the therapeutic implications. While current therapeutic approaches are able to control the effects of excessive adrenergic activation in heart failure syndrome, the underlying abnormalities of adrenergic control remain unaltered and can still cause progression to unmanageable end-stage heart failure. New therapeutic pathways are therefore being explored with a view to developing interventions that can directly modulate adrenergic over-activity and restore a more appropriate balance in neural control of the cardiovascular system. The book opens by examining current heart failure therapies. Advances in our understanding of autonomic regulation/dysregulation in heart failure are then discussed in detail, in the context of the search for more effective therapies. A concluding section addresses the role of autonomic nervous system denervation in heart failure. The authors are top scientists from leading research centers.