Chapter 1 Hemoglobin: Structure, Synthesis and Oxygen Transport -- Chapter 2 Sickle cell Anemia: History and Epidemiology -- Chapter 3 Overview of Sickle Cell Anemia Pathophysiology -- Chapter 4 Red Blood Cells and the Vaso-occlusive Process -- Chapter 5 Leukocytes in the vaso-occlusive process -- Chapter 6 Hypercoagulability and Sickle Cell Disease -- Chapter 7 Cardiovascular Adaptations to Anemia and the Role of Vascular Endothelium in Sickle Cell Disease Pathophysiology -- Chapter 8 Inflammation and Sickle Cell Anemia -- Chapter 9 Clinical Manifestations of Sickle Cell Anemia: Infants and Children -- Chapter 10 Treatment of Childhood Sickle Cell Disease -- Chapter 11 Priapism in Sickle Cell Disease: New aspects of pathophysiology -- Chapter 12 Clinical Manifestations and Treatment of Adult Sickle Cell -- Chapter 13 Hemoglobin SÝ Thalassemia, SC Disease and SD Disease: Clinical and Laboratorial Aspects -- Chapter 14 Sickle Cell Disease in Africa and the Arabian Peninsula: Current Management and Challenges -- Chapter 15 Genetic Factors modifying sickle cell disease severity -- Chapter 16 Future Perspectives for the Treatment of Sickle Cell.

Although sickle cell anemia was the first molecular disease to be identified, its complex and fascinating pathophysiology is still not fully understood. A single mutation in the beta-globin gene incurs numerous molecular and cellular mechanisms that contribute to the plethora of symptoms associated with the disease. Our knowledge regarding sickle cell disease mechanisms, while still not complete, has broadened considerably over the last decades. Sickle Cell Anemia: From Basic Science to Clinical Practice aims to provide an update on our current understanding of the disease�s pathophysiology and use this information as a basis to discuss its manifestations in childhood and adulthood. Current therapies and prospects for the development of new approaches for the management of the disease are also covered.