This book presents and describes a series of informative clinical cases with the aim of providing the reader with a clear understanding of the most frequent and challenging scenarios that a cardiologist may face during daily clinical practice. All major topics in modern clinical cardiology are addressed, including acute ischemic heart disease, conditions that mimic ischemic heart disease, heart failure and resynchronization therapy, cardiomyopathy, valvular heart disease, arrhythmias, and channelopathies. Guidance is provided on imaging techniques and their interpretation, patient management taking into account potential comorbidities, and follow-up appropriate to the clinical circumstances. The paradigmatic clinical cases in this book will serve as a sound basis for learning for medical students, residents, and others wishing to meet successfully the challenges posed by cardiac disease. In addition, the book will be a very useful reference for the more experienced cardiologist.