Epidemiology and risk factors.-Â{u0874}hophysiology.-Diagnosis -- Management of patients with CML -- Challenges of treatment: treatment-resistant CML -- Useful resources for your patients and caregivers.

This concise, clinically focused pocket handbook assembles and synthesizes the latest developments and trends in the diagnosis and treatment of CML and provides an authoritative and convenient summary of the latest progress in TKI trials, the molecular monitoring of CML responses, and the development of new therapies to overcome resistance and improve patient care. Chronic myeloid leukemia (CML) is a rare type of leukemia (1â€{u2830}er 100,000 people) but is the most common chronic myeloproliferative neoplasm. CML remains a key model for the improved understanding of the pathophysiology of a malignancy at a molecular level; CML was the first cancer to be associated with a recurring chromosome abnormality,Â{u7A29}ch generates the Philadelphia (Ph) chromosome and its associated fusion gene BCR-ABL1.Â{u4A25} clinical outcome for patients with CML has changed dramatically in the past 15 years andÂ{u4A29}s has been due to the development of tyrosine kinase inhibitors (TKIs), compounds that inhibit the activity of the oncogenic BCR-ABL1 protein.Â{u182E}number of first-, second- and third-generation TKIs are now available for theÂ{u4CA5}atment of CML, although a number of treatment challenges remain, not least the development of treatment-resistant CML.Â{u0872}allel to the development of specific drugs for treating CML, major advances have been made in the field of disease monitoring and standardization of response criteria.Â{uE000}