Cellular targets in innate and adaptive immunity -- Traffic of T lymphocytes -- Lymphocyte homing to peripheral epithelial tissues -- Chemokine biology of NK cells and ?? T cells -- Dendritic cell traffic control by chemokines -- Chemokine receptor-mediated signal transduction -- Chemokines in leukocyte transendothelial migration -- Natural chemokine antagonism and synergism -- Effector cell traffic-unrelated functions -- Crosstalk between chemokine, opioid, and vanilloid receptors -- Antimicrobial and related activities of chemokines -- Virus-encoded chemokine modulators as novel anti-inflammatory reagents -- Chemokine receptors in tissue cells and angiogenesis.

The discovery of interleukin-8 close to 20 years ago initiated a new field of research touching on many aspects of immunology and inflammation. Interleukin-8 is just one member of a large class of structurally related chemoattractant proteins, known as chemokines. Chemokines are involved in the traffic control of leukocytes, which bear the corresponding chemokine receptors on their surfaces. Today, it is clear that chemokines affect all aspects of immunology and even many unrelated fields, such as tissue development and tumor cell metastasis. Their fundamental contributions to chronic inflammatory diseases make them a principal target for the development of novel, anti-inflammatory therapeutics. This set of books* gives a state-of-the-art account of recent developments in this field in the form of summaries written by highly regarded experts. Volume I is focused on basic principles and progress in chemokine biology, and Volume II deals with issues related to chemokine-related drug development and potential therapeutic applications. These volumes provide both introductory and novel information for a broad readership, including clinicians and biomedical scientists. *See also K. Neote/G.L. Letts/B. Moser, Chemokine Biology - Basic Research and Clinical Application. Volume II: Pathophysiology of Chemokines. 2006, BirkhÃ{u5CE5}r, Progress in Inflammation Research, ISBN 3-7643-7195-1.