Preface -- Histone, Nucleosome and Chromatin Structure -- Histone Chaperones in the Assembly and Disassembly of Chromatin -- Chromatin Remodeling Complexes -- Regulating Chromatin by Histone Acetylation -- Histone Methylation in Chromatin Signaling -- Histone Ubiquitylation Control of Gene Expression -- Regulation of Chromatin Structure and Function by PARP-1 and ADP-ribosylation -- Histone phosphorylation and chromatin dynamics -- Reading histone modifications -- Properties and functions of histone variants -- Transcription through Chromatin -- Chromatin remodeling in DNA repair and replication -- Heterochromatin: A Critical Part of the Genome -- Emerging Areas of Chromatin Research -- Index

Chromatin is the combination of DNA and proteins that make up the genetic material of chromosomes. It is essential for packaging DNA, regulation of gene expression, DNA replication and repair. The audience for this book includes newly established scientists, graduate students and scientists seeking detailed overviews of various aspects of chromatin structure and function to gain entry into this field. The chapters in this book give a strong, updated groundwork about the fundamentals of chromatin which are essential to understand epigenetics. Some the fundamentals that this book covers include the structure and biochemistry of chromatin and the enzyme complexes that manage it