Redox Regulation of PTPs in Metabolism: Focus on Assays -- Quantitative Modeling of PTPs and Implications for Studying Metabolic Signaling -- Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism -- PTP1B and TCPTP in CNS Signaling and Energy Balance -- PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress -- Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling -- PTP1B in Obesity-Related Cardiovascular Runction -- Role of SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism -- Metabolic Effects of Neural and Pancreatic SHP2 -- Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism -- The Role of LMPTP in the Metabolic Syndrome -- Mitogen-Activated Protein Kinase Phosphatases in Metabolism -- Glycogen Metabolism and Lafora Disease -- Index

Tyrosine phosphorylation is a rapid and reversible protein modification catalyzed by the yin and yang activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). A multitude of PTPs have been implicated in human disease, with a growing number of PTPs now known to play major roles in prevalent metabolic diseases including obesity and type 2 diabetes. Recent studies into PTP function in the context of metabolism highlight the importance of understanding the specific substrates and binding partners of these enzymes, the regulation of PTP activity, and the cell/tissue specificity of PTP functions. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism