Part Background. Fatigue a phenomenon of modern age? On the history of fatigue -- Definitions, Epidemiology and etiological factors -- Pathophysiology and differentiation to other symptoms and diseases -- Immunopathology and pathogenesis -- Part Clinic. Motor fatigue and fatigability in MS -- Cognitive fatigue -- Personality factors and motivation -- Fatigue and depression -- Sleep-wake disorders -- Part Diagnostics. Clinical assessment instruments of fatigue -- Imaging methods and fatigue -- Electrophysiology and fatigue -- Expert opinion and sociomedical evaluation -- Part Therapy. Disease modifying drugs and fatigue -- Symptomatic pharmacotherapy and fatigue -- Non-pharmacological treatment and neurorehabilitation.

Fatigue is a major symptom in patients with multiple sclerosis (pwMS) and is mainly responsible for unemployment, early retirement but also social withdrawal. This book combines reporting of actually existing scientific knowledge with guidance for clinical practice. As such the book helps health care professionals in all countries to better understand fatigue symptoms but also to help patients to better cope with them. .