Part I Role of the Tumor Microenvironment -- An Overview of the Tumor Microenvironment and Response to Immunotherapy in Gastrointestinal Malignancies -- Part II Esophagus -- Approach to Immunotherapy in Oesophageal Cancer -- Perspective on the Immunotherapy of Esophageal Cancer -- Part III Stomach -- Immunotherapy of Gastric Cancer: Focus on Perioperative Strategies -- Stomach: The Standard of Care {plusmn} HER2 -- Perspective on the Immunotherapy of Gastric Cancer -- Part IV Colon -- Immunotherapy in dMMR/MSI-H Colon Cancer -- Immunotherapy in the Treatment of Advanced Colorectal Cancer -- Immunotherapy of Rectal Cancer -- Perspective on Immunotherapy of Colon Cancer: Challenges for the Future -- Part V HCC -- Immune Strategies for Gastrointestinal Cancer: HCC -- Immunotherapy in GI Cancers: Hepatocellular Carcinoma: Perspective -- Part VI Biliary Tract -- Immunotherapy of Biliary Tract Cancer -- Perspective on Immunotherapy Use in Biliary Tract Cancer -- Part VII Pancreas -- Immune Landscape of Pancreas Ductal Adenocarcinoma: Current Therapeutic Strategies and Future Perspective -- Perspective on the Immunotherapy of Pancreatic Cancer -- Part VIII Biomarkers for Immunotherapy in Gastrointestinal Cancers -- Biomarkers for Immunotherapy in Gastrointestinal Cancers.

This book provides an overview of the available evidence surrounding immunotherapy in gastrointestinal cancers, and discusses its future place in clinical practice. Immunotherapy has celebrated some astonishing therapeutic successes in a variety of cancer types and is becoming increasingly relevant in daily clinical practice. Currently, the predominant class of immunotherapeutic drugs is the so-called checkpoint inhibitors, which disengage the physiological brakes on the immune system, enabling a more effective anti-cancer immune response. Malignancies of the gastrointestinal tract, which account for the majority of cancer cases worldwide, are a major cause of morbidity and mortality, creating an urgent need for more effective therapies. A large number of clinical trials have evaluated the efficacy of cancer immunotherapy in gastrointestinal malignancies and demonstrated its potential in certain subsets of patients. This book will appeal to a wide readership, including oncologists, health care professionals in general and biomedical scientists.