Epidemiology and socioeconomic impact of infections in knee replacement -- Aetiology and pathogenesis of knee replacement infections.Biomaterials in artificial joint replacement. The role of the surface on bacteria-implant interactions -- In-vitro and in-vivo models for the study of prosthetic joint infections. Clinical manifestation. General and local symptoms. Diagnosis. Laboratory diagnosis -- Microbiological diagnosis -- Molecular analysis and histological evaluation -- Imaging -- Definitional criteria and algorithms of diagnosis. Treatment of knee replacement infections. Systemic antibiotic therapy -- Innovative pharmacological strategies -- Surgical approaches -- DAIR -- One stage -- Two stage -- Static spacers -- Dynamic spacers -- Arthrodesis -- Outcomes -- Complications -- Resistant germs. Current evidence on prevention of knee replacement infections. Medical optimization of patient prior to surgery -- Antibiotic prophylaxis during primary and revision joint replacement -- Preoperative management -- Intraoperative management -- Dental Procedures after joint replacement -- Thromboprophylaxis and haematomas -- Antibiotic impregnated cement -- Arthroplasty following Prior septic arthritis -- Antibiotic-loaded cement in primary and revision joint replacement -- Operative Room -- Tourniquet -- Intraarticular injection prior Joint replacement.

This book provides an in-depth overview of the aetiology, treatment and prevention of infections following knee arthroplasty. It presents up-to-date information on available techniques and salvage procedures for complex patients with infected, total knee arthroplasty. Divided into 5 sections, this book explores biomaterials, clinical manifestations, diagnosis, treatment and prevention, including preoperative optimisation, in order to reduce knee infections. This book is a valuable reference resource for practicing orthopaedic surgeons, residents, and medical students wishing to understand the fundamental concepts in infectious disease medicine needed in current orthopaedic practice.