This current book comprises state-of-the-art research results in the field of mechatronics and reliable systems engineering, gathering papers from almost all continents. Since the chapters represent contributions of research scholars who work in both governmental financed institutions and in the business environment, one could infer that they certainly reflect a clear picture of the developments in these cutting-edge sciences. Moreover, the contributions are not limited to mechatronics, as nowadays it has grown to embed all smart technical sciences. Medical applications based on nano-technologies - seemingly the most promising of all newly developed branches - could not be left out of this work. It is our belief that the book is useful to both students, who want to learn from the best scholars (as most of the authors hold a Ph.D. degree and are well-known professors), and to researchers in all areas of smart engineering, who will definitely find here hot topics meant to inspire them in their line of work.