Preface -- Part 1. PHARMACOLOGY AND MEDICINAL CHEMISTRY -- Part 2. CLINICAL PHARMACOLOGY -- Part 3. THE IMMUNE AND INFLAMMATORY RESPONSE IN THE BRAIN -- Part 4. NEUROPHARMACOLOGY: HISTAMINE AND BEHAVIOUR -- Part 5. NEUROPHARMACOLOGY: HISTAMINE AND SLEEP.

Research in the field of histamine receptors over the past 100 years went hand-in-hand with the development of modern pharmacology. Advances in histamine research led by outstanding scientists was so incisive that the clinical approach to treat allergies and gastrointestinal ailments was revolutionized. The pharmacological treatment of peptic ulcer and gastroesophageal reflux was indeed a revolution, as it ended the surgical intervention. The aim of this book is to cover the most important aspects of histamine receptor function and pharmacology in the central nervous system and to provide a comprehensive overview of the preclinical and clinical advances made in recent decades and the exciting prospects for the future. It highlights the clinical areas where there is a great need for new therapeutic approaches and where novel histaminergic agents may be useful for personalized medicine. .