History of Antisense Oligonucleotides -- Pharmacology of Antisense Therapeutic Agents -- Antisense Efficacy -- Antisense Blockade of Expression -- Antisense Tumor Therapy -- Antisense Inhibition of Protein Synthesis and Function -- c-Myb in Smooth Muscle Cells -- Antisense Therapy of Hepatitis B Virus Infection -- Antisense-Mediated Inhibition of Protein Synthesis -- Antisense rel A in Cancer -- Continuous Infusion of Antisense Phosphorothioate Therapeutics -- Protein Kinase-A Directed Antisense Therapy of Tumor Growth In Vivo -- Antisense Therapeutics in the Central Nervous System -- Comparative Pharmacokinetics of Antisense Oligonucleotides.

Leading researchers offer an authoritative survey and analysis of the latest findings on the rapid development of antisense oligonucleotides therapeutic and their application in various in vivo model systems. The book's high-profile contributors provide timely accounts of their state-of-the-art strategies, discussing such topics as the synthesis and purification of oligonucleotides, their selection for a particular gene target, different methods of administration, and the use of various cell lines and cell culture systems. They also examine questions of cellular uptake, in vitro biological activity, in vivo biological activity, the pharmacology and pharmacokinetics of oligonucleotides, and the application of oligonucleotides to the central nervous system.