1. Pathophysiology of hemophilia -- 2. Genetics of Hemophilia A and B -- 3. Inhibitors in Hemophilia A -- 4. Immune Tolerance In Patients with Hemophilia A -- 5. Hemophilia A: New drugs -- 6. Inhibitors in Hemophilia B -- 7. Immune Tolerance Induction in Hemophilia B -- 8. Hemophilia B: New Drugs -- 9. Management of Hemophilia Carriers -- 10. Pharmacoeconomic Aspects in Hemophilia -- 11. Assessment of Joint Health and Outcome Measures in Hemophilia -- 12. Musculoskeletal Medicine in Hemophilia -- 13. Management of Acute Hemarthrosis in Hemophilia (Including Joint Aspiration) -- 14. Hemophilic Arthropathy: Radiosynovectomy -- 15. Hemophilic Arthropathy: Arthroscopic Joint Debridement -- 16. Hemophilic Arthropathy: Total Joint Arthroplasty -- 17. Hemophilic Arthropathy: Other Orthopedic Procedures -- 18. Gene Therapy in Hemophilia: Latest Advances -- 19.A Summary of the Recent Recommendations of the WFH.

This book offers a comprehensive and state of the art overview of hemophilia management by reviewing all most recent advances and cutting edge information in this fast evolving field. As hemophilia patients are often affected by joint problems it also provides clear guidance on the surgical treatment of musculo-skeletal manifestations. The first part is devoted to the disease's pathophysiology (differentiating hemophilia A and B), genetics, pharmacotherapy - including replacement and non-replacement therapy - and gene therapy, as well as quality of life issues - also related to hemophilia carriers. The second part is then focused on joint problems, ranging from joint health assessment and pain control to surgical treatment of acute hemarthrosis and hemophilic arthropathy, i.e. radiosynovectomy, total joint arthroplasty and arthroscopic joint debridement. Written by experts drawn from leading institutions involved in treatment of hemophilia and related joint problems, this book offers a valuable resource to hematologists, orthopedic surgeons, rehabilitation physicians, radiologists, and pharmacy researchers.