Part I: Epistemology, Epidemiology, Psychopathology and History of Depression -- Chapter 1. The Study of Depression in the Frame of the new Research Paradigm in Psychiatry -- Chapter 2. Psychopathology of Depression in the Spectrum of Mood Disorders -- Chapter 3. Epidemiology of Depression: Burden of Disease, Trends, and the Con-tributions of Social Epidemiology to the Study of its Causes -- Chapter 4. Idioms of Depression in Contemporary Individualistic Societies: Unit-ed States and Chile -- Part II: Etiopathogenic Theories and Models -- Chapter 5. Contemporary Psychodynamic Theories on Depression -- Chapter 6. Theory and Interventions in Cognitive Behavioral Therapy for Depression -- Chapter 7. Genetic and Epigenetic Determinants of Depression: From Basic Re-search to Translational Medicine -- Chapter 8. Neurobiology of Depression -- Chapter 9. A Dimensional and Dynamic Approach to the Neurobiology of Mood Disorders: On Intermediate Phenotypes and their Interaction with Early Stress -- 10. Psychophysiology and Psychoneuroendocrinology of Stress and Re-ward in Depression -- Chapter 11. Depression and (Expert) Culture: Psychiatric, Regulatory and Moral Frameworks Underpinning the Absence of Depression in Occupation-al Health in Chile -- Chapter 12. Poverty, Social Inequity, and Depression -- Part III: Evolution and Development as an Integrating Framework -- Chapter 13. An Integrative Developmental Psychopathology Approach to Depression -- Chapter 14. Depression and Personality Dysfunction: Moving from Descriptive Comorbidity to the Identification of Common Intermediate Phenotypes -- Chapter 15. Gender and Depression: Women, Transgender and Gender Non-Conforming Depression -- Part IV: Clinical Practice as a Meeting Place for Etiopathogenic Models -- Chapter 16. Models in Depression and Clinical Judgment, or how to use Different Etiopathogenic Models with a Particular Patient.

This book reviews the different theories and models that seek to explain the causes of depression from different perspectives, from the molecular to the socio-cultural level. Depression is a complex psychopathological construct of high phenotypic heterogeneity, which must be understood as a phenomenon in which different explanatory levels interact with each other. However, very little is known about this interaction. The aim of this book is to provide clinical psychologists and psychiatrists a better knowledge of the interaction of different etiopathogenic levels, in order to help these professionals make better therapeutic decisions when treating depressed patients. Chapters in this volume review etiopathogenic theories and models of depression developed by different disciplines and fields of research, such as clinical psychology, psychiatry, genetics, neurobiology, psychophisiology, psychoneuroendocrinology and psychosocial studies, and examine certain conditions where the integrated consideration of different explanatory levels illuminates how depression originates and is maintained. In each chapter, authors critically review the state of the art in their field of expertise and explain the weak points of their own theories and their possible openness or connection to alternative theories or models. Etiopathogenic Theories and Models in Depression will be a valuable resource for clinical psychologists, psychiatrists and other health professionals working with depressed patients, as well as to researchers investigating how depression originates and is maintained, presenting an integrated perspective of high translational value for clinical practice.