Visionary papers -- Evolution of an Adaptive Information System for Precision Medicine -- Security Risk Estimation and Management in Autonomous Driving Vehicles -- BPMN Extensions for Modeling Continuous Processes -- Sensor Data Stream Selection and Aggregation for the Ex Post Discovery of Impact Factors on Process Outcomes -- Requirements Elicitation for Applications Running on a Blockchain: Preliminary Results -- ISGE: A conceptual Model-based Method to correctly manage genome data -- Case Level Counterfactual Explanation in Process Mining -- Evaluating Fidelity of Explainable Methods for Predictive Process Analytics -- Data-Driven Process Performance Measurement and Prediction: A Process-Tree-Based Approach -- Detecting Privacy, Data and Controlflow Deviations in Business Processes -- Dynamic Strategic Modeling for Alliance-Driven Data Platforms: The Case of Smart Farming -- Modelling Cyber-physical Security in Healthcare Systems -- Declarative Process Discovery: Linking Process and Textual Views -- A Tool for Computing Probabilistic Trace Alignments -- Innovative tools and prototypes -- Applied Predictive Process Monitoring and Hyper Parameter Optimization in Camunds -- SmartRPA: A Tool to Reactively Synthesize Software Robots from User Interface Logs -- PatternLens: Inferring evolutive patterns from web API usage logs -- Designing a Self-Service Analytics System for Supply Base Optimization.

This book constitutes the thoroughly refereed proceedings of the CAiSE Forum 2021 which was held as part of the 33rd International Conference on Advanced Information Systems Engineering, CAiSE 2021, in June 2021. The conference was held virtually due to the COVID-19 pandemic. The CAiSE Forum is a place within the CAiSE conference for presenting and discussing new ideas and tools related to information systems engineering. Intended to serve as an interactive platform, the Forum aims at the presentation of emerging new topics and controversial positions, as well as demonstration of innovative systems, tools and applications. This year's theme was "Intelligent Information Systems". The 18 full papers presented in this volume were carefully reviewed and selected for inclusion in this book.