Incluye referencias bibliográficas e índice

Historical background of discoid and systemic lupus erythematosus -- The definition and classification of systemic lupus erythematosus -- Environmental aspects of lupus -- The epidemiology of systemic lupus erythematosus -- Overview of pathogenesis of systemic lupus erythematosus -- The genetics of human lupus -- The genetics of murine systemic lupus erythematosus -- Apoptosis -- The interaction of T cells with cells of the innate immune system and B cells in the pathogenesis of SLE -- Cytokines and interferons in lupus -- B cells in systemic lupus erythematosus -- Abnormalities in immune complex clearance and Fcy receptor function -- Complement and systemic lupus erythematosus -- Mechanisms of acute inflammation and vascular injury in systemic lupus erythematosus -- Idiotypes and idiotype networks -- The importance of sex hormones in systemic lupus erythematosus -- Neuroendocrine immune interactions: principles and relevance to systemic lupus erythematosus -- Animal models of systemic lupus erythematosus -- Pathogenesis of atherosclerosis in lupus -- Autoantigens and defects in immune tolerance in lupus -- The structure and derivation of antibodies and autoantibodies -- Antinuclear antibodies: an overview -- Antibodies to DNA -- Antibodies to histones and nucleosome-related antigens -- Antibodies to Ro/SSA and La/SSB -- Antibodies to spliceosomal components -- The lupus anticoagulant and antiphospholipid antibodies -- Other serologic abnormalities in systemic lupus erythematosus -- Pathomechanisms of cutaneous lupus erythematosus -- Lupus-specific skin disease (cutaneous LE) -- Lupus-nonspecific skin disease -- The clinical presentation of systemic lupus erythematosus -- The musculoskeletal system -- Cardiovascular manifestations of lupus -- Pulmonary manifestations of systemic lupus erythematosus --

Clinical apsects of vasculitis and selected cutaneovascular manifestations of systemic lupus erythematosus -- The nervous system -- Psychopathology of lupus and neuroimaging -- Sjogren's syndrome -- Ocular, aural, and oral manifestations -- Hematologic and lymphoid abnormalities in systemic lupus erythematosus -- Gastrointestinal and hepatic manifestations -- Systemic lupus erythematosus in childhood and adolescence -- Drug-induced lupus -- Infections in systemic lupus erythematosus -- Serum and plasma protein abnormalities and other clinical laboratory determinations in systemic lupus erythematosus -- Clinical indices in the assessment of lupus -- Clinical application of serologic abnormalities in systemic lupus erythematosus -- Differential diagnosis and disease associations -- Mixed connective-tissue disease and overlap syndromes -- The mother in systemic lupus erythematosus -- The fetus in systemic lupus erythematosus -- Neonatal lupus -- Reproductive issues in women with autoimmune disease -- Lupus nephritis: pathology and pathogenesis -- Clinical and laboratory features of lupus nephritis -- Principles of therapy and local measures -- Nonsteroidals and salicylates for systemic lupus erythematosus -- Antimalarial therapies -- Systemic glucocorticoid therapy in systemic lupus erythematosus -- Immunosuppressive drug therapy -- Nonpharmacologic and complementary therapeutic modalities -- Fibromyalgia in SLE and the use of complementary and alternative medicine -- Hormones and gender-related issues -- Clinical and management aspects of the antiphospholipid antibody syndrome -- Additional therapies used in the management of lupus -- Adjunctive measures and issues: allergies, antibiotics, vaccines and disability -- Issues in drug development in SLE: clinical trial design, outcome, measures, and biomarkers -- Prognosis, mortality, and morbidity in systemic lupus erythematosus -- Biologics and stem cell therapies for lupus -- Appendics: A patient's guide to lupus erythematosus -- Lupus resource materials -- The medical outcome survey short-form general health survey.