Chapter 1: Mast cell biology in health and disease.-Chapter 2: Clinical approach to a patient with elevated serum tryptase: implications of acute versus basally elevated levels. -Chapter 3: Urinary markers of mast cell disease and their role in diagnosis and management -- Chapter 4: Skin disease in mastocytosis -- Chapter 5: Pediatric Mastocytosis -- Chapter 6: Gastrointestinal Manifestations of Systemic Mastocytosis -- Chapter 7: Systemic Mastocytosis and Bone-Related Events -- Chapter 8:Anaphylaxis in Mastocytosis -- Chapter 9: Venom Allergy and Management in Mastocytosis -- Chapter 10: Drug Allergy and Perioperative Management of Mastocytosis.-Chapter 11: Mastocytosis in Pregnancy.-Chapter 12: KIT and Other Mutations in Mastocytosis.-Chapter 13: Management of the Hematologic Disease in Mastocytosis -- Chapter 14: Tyrosine Kinase Inhibitors in Systemic Mastocytosis -- Chapter 15: International Support and Advocacy for Mast Cell Disease Patients and Caregivers -- Chapter 16: Mastocytosis: Overview of Diagnosis and Classification. .

This unique book offers an in-depth, best-practices guide to diagnosis and management of mastocytosis, a too-often underdiagnosed disease. Mastocytosis: A Comprehensive Guide will open with a general overview and discussion of mast cell biology, addressing tryptase and other diagnostic markers in detail. Comprehensive diagnostic criteria and classification will follow, with special emphasis on commonly-seen related manifestations: skin disease, pediatric mastocytosis, gastrointestinal indicators, osteoporosis, anaphylaxis, venom and drug allergy, and pregnancy. Mastocytosis will be an ideal resource for not only the allergist confronted with this condition, but for a growing, multi-disciplinary audience of hematologists, gastroenterologists, dermatologists, pediatricians, primary care providers and other clinicians who encounter this disease in their patients. .