Preface -- Between Hype and Hope, on the Cutting Edge of Precision Cancer Medicine -- Molecular Diagnostics in Cancer: a Fundamental Component of Precision Oncology -- Clinical Interpretation -- Precision Cancer Medicine and Clinical Trial Design -- Resistance to Anti-Cancer Therapeutics -- Exceptional Responders -- Immunogenomics -- Managing Germline Findings from Molecular Testing in Precision Oncology -- Ethical, legal, and social implications of precision cancer medicine -- Liquid Biopsy: Translating Minimally Invasive Disease Profiling From The Lab To The Clinic -- Data Portals and Analysis -- Index.

This comprehensive book was written by leading researchers in the emerging and changing field of precision cancer medicine. Precision cancer medicine entails connecting the right molecular diagnosis to the right treatment plan for individual patients. The textbook covers a range of topics from basic science to clinical application for patient care. Precision cancer medicine includes multi-disciplinary fields of research expertise ranging from genomics, pathology, oncology, hereditary genetics, bioinformatics, immunology, cancer biology, and bioethics. Basic topics include molecular diagnostics, liquid biopsy, immunogenomics, drug resistance mechanisms, and bioinformatics analyses of big data. The clinical topics include clinical interpretation, hereditary cancers, designs of basket clinical trials, exceptional responders, and the ethical, legal, and social implications of clinical genomics research. Readers who are involved in one of the specialities of precision cancer medicine can benefit from this book through exposure to other fields. Any level of training or professional practice can benefit from the broad exposure this book can provide. .