Molecular Control of HIV and SIV Latency -- Assays to Measure Latency, Reservoirs and Reactivation -- The Antiviral Immune Response and its Impact on the HIV-1 Reservoir -- Nonhuman Primate Models for Studies of AIDS Virus Persistence During Suppressive Combination Antiretroviral Therapy -- SIV Latency in Macrophages in the CNS -- Mathematical models of HIV latency -- Residual Immune Activation and Latency -- Immune Interventions to Eliminate the HIV Reservoir -- Cell and Gene Therapy for HIV Cure.

This volume summarizes recent advances in understanding the mechanisms of HIV-1 latency, in characterizing residual viral reservoirs, and in developing targeted interventions to reduce HIV-1 persistence during antiretroviral therapy. Specific chapters address the molecular mechanisms that govern and regulate HIV-1 transcription and latency; assays and technical approaches to quantify viral reservoirs in humans and animal models; the complex interchange between viral reservoirs and the host immune system; computational strategies to model viral reservoir dynamics; and the development of therapeutic approaches that target viral reservoir cells. With contributions from an interdisciplinary group of investigators that cover a broad spectrum of subjects, from molecular virology to proof-of-principle clinical trials, this book is a valuable resource for basic scientists, translational investigators, infectious-disease physicians, individuals living with HIV/AIDS and the general public.