Principles of atomic force microscopy -- Atomic force microscopy-based single molecule force spectroscopy for biological applications -- Single molecule in situ detection on cell membrane and label molecule distributions using AFM/NSOM -- AFM imaging-force spectroscopy combination for molecular recognition at the single-cell level -- High resolution imaging of cells using atomic force microscopy -- The hyphenated technique of high speed atomic force microscopy and super resolution optical detection system -- AFM/Raman spectrum based imaging system and its application in single molecule detection -- Observing drug interactions with cell at nanoscale using atomic force microscopy -- In situ measuring mechanical properties of normal and disease cells -- High resolution AFM and its applications in molecular and cell biology.

The book addresses new achievements in AFM instruments - e.g. higher speed and higher resolution - and how AFM is being combined with other new methods like NSOM, STED, STORM, PALM, and Raman. This book explores the latest advances in atomic force microscopy and related techniques in molecular and cell biology. Atomic force microscopy (AFM) can be used to detect the superstructures of the cell membrane, cell morphology, cell skeletons and their mechanical properties. Opening up new fields of in-situ dynamic study for living cells, enzymatic reactions, fibril growth and biomedical research, these combined techniques will yield valuable new insights into molecule and cell biology. This book offers a valuable resource for students and researchers in the fields of biochemistry, cell research and chemistry etc.