MARC details
| 000 -CABECERA |
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| campo de control de longitud fija |
06045cam a2200433Ki 4500 |
| 001 - NÚMERO DE CONTROL |
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96079 |
| 003 - IDENTIFICADOR DEL NÚMERO DE CONTROL |
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ES-MaUEC |
| 005 - FECHA Y HORA DE LA ÚLTIMA TRANSACCIÓN |
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20230102112737.0 |
| 006 - CÓDIGOS DE INFORMACIÓN DE LONGITUD FIJA--CARACTERÍSTICAS DEL MATERIAL ADICIONAL |
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m o d |
| 007 - CAMPO FIJO DE DESCRIPCIÓN FÍSICA--INFORMACIÓN GENERAL |
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cr |n||||||||| |
| 008 - DATOS DE LONGITUD FIJA--INFORMACIÓN GENERAL |
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170529s2017 sz o 001 0 eng d |
| 020 ## - NÚMERO INTERNACIONAL ESTÁNDAR DEL LIBRO |
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| Número Internacional Estándar del Libro |
3319575538 |
| Información calificativa |
(electronic bk.) |
| 020 ## - NÚMERO INTERNACIONAL ESTÁNDAR DEL LIBRO |
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| Número Internacional Estándar del Libro |
9783319575537 |
| Información calificativa |
(electronic bk.) |
| 020 ## - NÚMERO INTERNACIONAL ESTÁNDAR DEL LIBRO |
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| ISBN cancelado o inválido |
331957552X |
| 020 ## - NÚMERO INTERNACIONAL ESTÁNDAR DEL LIBRO |
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| ISBN cancelado o inválido |
9783319575520 |
| 040 ## - FUENTE DE LA CATALOGACIÓN |
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| Centro catalogador/agencia de origen |
YDX |
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YDX |
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ES-MaUEC |
| Lengua de catalogación |
spa |
| 050 #4 - SIGNATURA TOPOGRÁFICA DE LA BIBLIOTECA DEL CONGRESO |
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| Número de clasificación |
QP552.M44 |
| Número de documento/Ítem |
T447 2017 EB |
| 066 ## - JUEGOS/CONJUNTO DE CARACTERES UTILIZADOS/PRESENTES |
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| Juego/conjunto de caracteres alternativo G0 o G1 |
(S |
| 245 04 - MENCIÓN DE TÍTULO |
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| Título |
The structural basic of arrestin functions |
| Mención de responsabilidad, etc. |
Vsevolod V. Gurevich, editor. |
| 264 #1 - PRODUCCIÓN, PUBLICACIÓN, DISTRIBUCIÓN, FABRICACIÓN Y COPYRIGHT |
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| Producción, publicación, distribución, fabricación y copyright |
Cham |
| Nombre del de productor, editor, distribuidor, fabricante |
Springer |
| Fecha de producción, publicación, distribución, fabricación o copyright |
2017. |
| 300 ## - DESCRIPCIÓN FÍSICA |
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| Extensión |
1 recurso en línea |
| 336 ## - TIPO DE CONTENIDO |
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| Término de tipo de contenido |
Texto |
| Código de tipo de contenido |
txt |
| Fuente |
rdacontent |
| 337 ## - TIPO DE MEDIO |
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| Nombre/término del tipo de medio |
electrónico |
| Código del tipo de medio |
c |
| Fuente |
rdamedia |
| 338 ## - TIPO DE SOPORTE |
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| Nombre/término del tipo de soporte |
recurso electrónico |
| Código del tipo de soporte |
cr |
| Fuente |
rdacarrier |
| 347 ## - CARACTERÍSTICAS DEL ARCHIVO DIGITAL |
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| Tipo de archivo |
text file |
| Formato de codificación |
PDF |
| 500 ## - NOTA GENERAL |
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| Nota general |
Incluye índice |
| 500 ## - NOTA GENERAL |
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| Nota general |
SpringerLink |
| -- |
Springer Biomedical and Life Sciences eBooks 2017 English+International |
| 505 0# - NOTA DE CONTENIDO CON FORMATO |
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| Enlace |
880-01 |
| Nota de contenido con formato |
Preface; Contents; Introduction; 1 Arrestins: Discovery of the Family and Functional Role of Conformational Flexibility; Abstract; Brief History of Arrestins; The Functional Cycle of Arrestins; The Structural Evidence for Distinct Arrestin Conformations; Preferential Interaction of Signalling Proteins with Arrestins in Particular Conformations; Acknowledgements; References; 2 Overview of Arrestin Mediated Signaling with Receptors and Non-receptor Binding Partners; Abstract; References; Localization of Functional Elements on Arrestins. |
| 505 8# - NOTA DE CONTENIDO CON FORMATO |
|---|
| Nota de contenido con formato |
5 Arrestin-3: The Structural Basis of Lower Receptor SelectivityAbstract; Introduction; Arrestin-3 Structure; Comparisons to the Rhodopsin-Arrestin-1 Complex; Acknowledgements; References; 6 Phosphate Sensor and Construction of Phosphorylation-Independent Arrestins; Abstract; Early Biochemistry and Structure-Function Characterization; Towards an Allosteric Model for Arrestin; Applications; References; 7 Comprehensive Analysis of the Role of Arrestin Residues in Receptor Binding; Abstract; Introduction: The Role of Arrestin in GPCR Trafficking and Signaling. |
| 505 8# - NOTA DE CONTENIDO CON FORMATO |
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| Nota de contenido con formato |
Membrane Interactions of Arrestin-1 and Binding StoichiometryPharmacological Relevance of Phosphobarcodes for Arrestin-Dependent Signaling; Acknowledgements; References; 8 How Arrestin Recognizes and Binds Active GPCRs; Abstract; The Pre-complex; Transition to the High-Affinity Complex; References; 9 Localization of Conformational Dynamics of Arrestins by HDX-MS; Abstract; What Can HDX-MS Reveal About Protein Conformation?; Introduction to Arrestin Structure; Arrestin Activation Mechanism Revealed by HDX-MS; Conformational Mechanism of Arrestin Selectivity Revealed by HDX-MS; Perspectives. |
| 505 8# - NOTA DE CONTENIDO CON FORMATO |
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| Nota de contenido con formato |
Molecular Mechanism of Arrestin-1 Engagement with Rhodopsin Revealed by Scanning MutagenesisScanning Mutagenesis as a Tool for GPCR Pharmacology Elucidation; Phosphorylation Defines the Nature of GPCR-Arrestin Interactions; Inactive Arrestin-1 and Its Key Regulation Sites; Pre-activation of Arrestin-1 by C-Tail Exchange Mechanism; Establishment of an Initial Phosphorylation-Dependent Binding; Activation and Phosphorylation States of the GPCR Influence the Conformation of the Final Complex; Active GPCR Recognition on a Single Residue Scale; GPCR Activation-Sensing Residues of Arrestin-1. |
| 520 3# - SUMARIO, ETC. |
|---|
| Sumario, etc. |
This volume summarizes our current understanding of the structural basis of the functions of arrestin family of proteins. Arrestins were first discovered as key players in the desensitization of G protein-coupled receptors (GPCRs). Recent studies showed that arrestins are important signal transducers in their own right, organizing multi-protein complexes and scaffolding numerous signaling cascades that regulate cell proliferation, differentiation, and apoptotic death. Here arrestin functions are described primarily from the structural prospective. The book covers basal structure of arrestin proteins, receptor binding-induced conformational changes in arrestins, as well as the structure of "pre-activated" mutants. Particular focus is on the arrestin elements interacting with numerous binding partners, GPCRs and cytoplasmic signaling proteins. We expect that this information and insights will help to understand and exploit the phenomenon of signaling bias, which is a new promising direction in drug discovery. The chapters are written by the world-class specialists in the field, mostly the people who actually contributed the data discussed. The book gives coherent historical prospective and describes the most recent findings. The book would be particularly useful for scientists in academia and industry working in the fields of pharmacology, cell biology, structural biology, and drug discovery. We expect that the focus on the molecular basis of protein-protein interactions would help to develop novel tools for engaging this important type of targets for research and therapeutic purposes. |
| 988 ## - NOTA LOCAL 598 |
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| Nota local 598 (boletines) |
EBOOK, asignarmaterias, EBSPRINGER_2017D |
| 650 #7 - PUNTO DE ACCESO ADICIONAL DE MATERIA--TÉRMINO DE MATERIA |
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| Término de materia o nombre geográfico como elemento de entrada |
Proteínas G |
| Fuente del encabezamiento o término |
embne |
| Número de control del registro de autoridad o número normalizado |
(OCoLC)fst01892761 |
| -- |
|
| 9 (RLIN) |
147588 |
| 700 1# - PUNTO DE ACCESO ADICIONAL--NOMBRE DE PERSONA |
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| Nombre de persona |
Gurevich, Vsevolod V. |
| 9 (RLIN) |
85661 |
| 856 40 - LOCALIZACIÓN Y ACCESO ELECTRÓNICOS |
|---|
| Identificador Uniforme del Recurso |
https://go.openathens.net/redirector/universidadeuropea.es?url=http://link.springer.com/10.1007/978-3-319-57553-7 |
| Nota pública |
Acceso a este recurso digital (usuarios Universidad Europea de Madrid) |
| 880 8# - REPRESENTACIÓN GRÁFICA ALTERNATIVA |
|---|
| Enlace |
505-01/(S |
| a |
3 Initial Crystallographic Studies of Visual Arrestin: Insights and PerspectivesAbstract; Early Biochemical Studies; What the Structural Biologists Knew; Crystallographic Studies; Quaternary Structure; References; 4 Structural Basis for β-Arrestins in GPCR Trafficking; Abstract; Introduction; Overview of Clathrin Mediated Endocytosis; Overview of β-Arrestin-Mediated Endocytosis; Structural View of β-Arrestin-Mediated Endocytosis; Structure of Basal and Active β-Arrestin in Endocytosis; Structure of β-Arrestin as an Endocytic Adaptor; References. |
| 998 ## - DATOS ESTADÍSTICOS |
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| Fecha de catalogación |
02/2018 |
| Tipo de materia |
E-book |
| Catalogador |
|
| Catalogado |
Sí |
| 999 ## - NÚMEROS DE CONTROL DE SISTEMA (KOHA) |
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| -- |
1 |