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| 003 - IDENTIFICADOR DEL NÚMERO DE CONTROL |
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ES-MaUEC |
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140317s2014 gw | s |||| 0|eng d |
| 020 ## - NÚMERO INTERNACIONAL ESTÁNDAR DEL LIBRO |
|---|
| Número Internacional Estándar del Libro |
9783642353741 |
| 024 7# - IDENTIFICADOR DE OTROS ESTÁNDARES |
|---|
| Número estándar o código |
10.1007/978-3-642-35374-1 |
| Fuente del número o código |
doi |
| 040 ## - FUENTE DE LA CATALOGACIÓN |
|---|
| Centro/agencia modificador |
ES-MaUEC |
| 050 #4 - SIGNATURA TOPOGRÁFICA DE LA BIBLIOTECA DEL CONGRESO |
|---|
| Número de clasificación |
RA1229 |
| Número de documento/Ítem |
.R453 2014 |
| 100 1# - ENTRADA PRINCIPAL--NOMBRE DE PERSONA |
|---|
| Nombre de persona |
Reichl, Franz-Xaver. |
| Término indicativo de función/relación |
editor literario |
| 9 (RLIN) |
85537 |
| Número de control del registro de autoridad o número normalizado |
Local |
| 245 10 - MENCIÓN DE TÍTULO |
|---|
| Título |
Regulatory Toxicology |
| Mención de responsabilidad, etc. |
edited by Franz-Xaver Reichl, Michael Schwenk. |
| 260 ## - PUBLICACIÓN, DISTRIBUCIÓN, ETC. |
|---|
| Lugar de publicación, distribución, etc. |
Berlin, Heidelberg |
| Nombre del editor, distribuidor, etc. |
Springer International Publishing |
| Fecha de publicación, distribución, etc. |
2014 |
| 300 ## - DESCRIPCIÓN FÍSICA |
|---|
| Extensión |
1 recurso en línea (XXIV, 946 p.) |
| Otras características físicas |
144 ilustraciones, 70 ilustraciones en color eReference. |
| 336 ## - TIPO DE CONTENIDO |
|---|
| Término de tipo de contenido |
Texto (visual) |
| Código de tipo de contenido |
txt |
| Fuente |
rdacontent |
| 337 ## - TIPO DE MEDIO |
|---|
| Nombre/término del tipo de medio |
electrónico |
| Código del tipo de medio |
c |
| Fuente |
rdamedia |
| 338 ## - TIPO DE SOPORTE |
|---|
| Nombre/término del tipo de soporte |
recurso electrónico |
| Código del tipo de soporte |
cr |
| Fuente |
rdacarrier |
| 505 0# - NOTA DE CONTENIDO CON FORMATO |
|---|
| Nota de contenido con formato |
Foreword -- Introduction -- Operation mode of regulatory toxicology -- Aims and institutions -- Aims and mission -- Application areas -- National and international collaboration -- Procedures and standards -- The regulatory process -- Quality assurance in regulatory toxcicology -- Toxicological risk assessment -- Methodological repertoire -- Toxicological tests -- Characterization of physicochemical parameters -- Examination of acute and chronic toxicity -- Examination of organ-toxicity and of laboratory parameters -- Specific tests for neurotox , immunotox, allergy, irritation, reprotox and carcinogenicity -- Toxicity testing in vitro -- New and future toxicological assays -- Computer-based prediction models -- Metabolism tests -- Toxicokinetic tests -- Toxicodynamic tests -- Omics -- International regulation for toxicological test procedures -- Data acquisition in humans -- Epidemiological methods -- Studies in volunteers -- Chemical analysis in toxicology (New) -- Toxicostatistics and models -- Statistical evaluation methods -- Dose-response analysis, identification of threshold levels -- Extrapolation-procedures for carcinogenic and non-carcinogenic compounds -- Probabilistic methods -- Toxicodynamic models -- Toxicokinetic models -- Estimation of exposure -- Exposure analysis for indoor contaminants -- Exposure scenarios -- Use of toxiological data -- Quality criteria for primary literature -- Data-mining -- Paradigms use in risk evaluation -- Toxicological paradigms -- Do carcinogens have a threshold dose? pro and contra -- Single compounds vs combination effects -- Biomolecules vs smaller chemicals -- Sensitive humans vs average persons -- Assessment paradigmas -- Extrapolation factors and safety factors -- Background exposure vs additional exposure in human biomonitoring -- Adverse effects vs non-adverse effects -- ADI vs MOS principle -- Precaution principle vs hazard control -- Hygienic vs toxicological approaches -- Protected property and protection level -- Risk characterization and risk evaluation -- The risk concept -- CurrentÂ{u0CAF}le of the term "risk" -- Risk cycles -- Risk minimization in drug development -- Data required for risk evaluation -- Importance of physical-chemical properties -- Importance of intrinsic toxic properties -- Importance of metabolism and of mechanism of action -- Importance of the extrapolation to lower doses in risk assessment -- Importance of exposure level for risk assessment -- Risk characterization -- Risk assessment -- Elements of risk assessment -- Risk comparison -- Risk-benefit considerations -- Risk assessment in different jurisdictions -- Reach as a regulatory instrument (New) -- Risk management and risk communication -- Risk management -- Purpose of risk management -- Assessment of limit values -- Deduction of limit values in different areas -- Registration and approval -- Classification and labelling -- Monitoring unwanted exposures and effects -- Restrictions and prohibitions -- Observance of susceptible population groups -- The toxicological expert report -- Risk management in toxicological emergencies -- Risk communication and participation of affected people -- Institutionalized participation -- The technique of risk communication -- Dealing with diseases that have been attributed to chemical exposures -- Addendum: tables and lists -- Checklist: Toxicological risk assessment in practice -- Glossary and risk terms -- Limit values, guideline values, tables -- Proposed additional chapters onÂ{u5D28}hics in toxicology and expansion of the chapter dealing withÂ{u9B6D}munotoxicology. |
| 520 ## - SUMARIO, ETC. |
|---|
| Sumario, etc. |
This book will be written by experts for professionals, scientists and all those involved in toxicological data generation and decision-making. It is the updated and expanded version of a monograph published in German in 2004.Âèemical safety is regulated on various levels including production, storage, transport, handling, disposal or labelling. This book deals comprehensively with the safety-ensuring methods and concepts employed by regulatory agencies, industry and academics. Toxicologists use experimental and scientific approaches for data collection, e.g. about chemical hazards, physicochemical features or toxicokinetics. The respective experimental methods are described in the book. Toxicologists also deal with much insecurity in the exposure and effect scenarios during risk assessment. To overcome these, they have different extrapolation methods and estimation procedures at their disposal. The book describes these methods in an accessible manner. Differing concepts from one regulation area to another are also covered. Reasons and consequences become evident when reading the book. Altogether, the book Regulatory Toxicology will serve as an excellent reference. |
| 650 #7 - PUNTO DE ACCESO ADICIONAL DE MATERIA--TÉRMINO DE MATERIA |
|---|
| Fuente del encabezamiento o término |
embne |
| 9 (RLIN) |
144870 |
| Término de materia o nombre geográfico como elemento de entrada |
Toxicología industrial |
| 700 1# - PUNTO DE ACCESO ADICIONAL--NOMBRE DE PERSONA |
|---|
| Nombre de persona |
Schwenk, Michael |
| Término indicativo de función/relación |
editor literario |
| 9 (RLIN) |
85538 |
| Número de control del registro de autoridad o número normalizado |
Local |
| 856 40 - LOCALIZACIÓN Y ACCESO ELECTRÓNICOS |
|---|
| Identificador Uniforme del Recurso |
https://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-3-642-35374-1 |
| Nota pública |
Acceso a este recurso digital (usuarios Universidad Europea de Madrid) |
| 999 ## - NÚMEROS DE CONTROL DE SISTEMA (KOHA) |
|---|
| -- |
1 |
| 907 ## - TRANSACCIONES MILLENIUM |
|---|
| id bib interno millenium |
.b12820696 |
| fecha actualizac reg bib |
10-10-17 |
| fecha creacion reg bib |
01-10-14 |
| 942 ## - ELEMENTOS DE PUNTO DE ACCESO ADICIONAL (KOHA) |
|---|
| Fuente del sistema de clasificación o colocación |
Library of Congress Classification |
| Tipo de ítem Koha |
LIBRO-E NO PRÉSTAMO |
| 945 ## - ITEM MILLENIUM |
|---|
| Signatura |
RA1229 .R453 2014 EB |
| Número de copia |
1 |
| Código de barras |
eBOOK |
| Agencia |
0 |
| Localización del ejemplar (ubicación) |
mae |
| Código 2 (categoría) |
- |
| Precio |
EUR0.00 |
| Mensaje (popup en cliente staff) |
- |
| Mensaje (visible en OPAC) |
- |
| Estado |
b |
| Tipo de ejemplar |
15 |
| Total de préstamos |
0 |
| Total de renovaciones |
0 |
| Préstamos del año en curso |
0 |
| Préstamos del año anterior |
0 |
| Identificador de la copia de ejemplar en Millennium |
.i11549907 |
| Fecha de creación del ejemplar |
06-04-17 |
| 988 ## - NOTA LOCAL 598 |
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| Nota local 598 |
EBSPRINGER |
| 998 ## - FONDO MILLENIUM |
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m |
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| Fecha creación |
- - |
| Tipo de registro |
m |
| Tipo de materia |
E-book |
| e |
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| Idioma |
eng |
| País |
gw |
| h |
0 |