Neuroanatomy and Pathology of Sporadic Alzheimer's Disease
Braak, Heiko
Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak, Kelly Del Tredici. - Cham, Switzerland Springer 2015 - 1 recurso en línea (XI, 162 páginas) 48 ilustraciones, 44 ilustraciones en color - Advances in Anatomy, Embryology and Cell Biology 215 0301-5556 .
Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations.ÂÂ
As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail.
9783319126791
10.1007/978-3-319-12679-1 doi
Geriatría
Patología
Neurociencias
RC523 / 2015 EB
Neuroanatomy and Pathology of Sporadic Alzheimer's Disease by Heiko Braak, Kelly Del Tredici. - Cham, Switzerland Springer 2015 - 1 recurso en línea (XI, 162 páginas) 48 ilustraciones, 44 ilustraciones en color - Advances in Anatomy, Embryology and Cell Biology 215 0301-5556 .
Prologue -- General Morphology of Alzheimer-associated intraneuronal pathology -- Consistent and systematic changes in the distribution pattern of intraneuronal inclusions render staging possible -- Basic organization of involved structures -- Presymptomatic stages -- General morphology of Alzheimer-associated extracellular pathology -- Symptomatic stages -- The progression of cortical lesions mimics the pattern of myelination in reverse order -- Tauopathies -- CSF biomarkers and imaging techniques -- The staging hypothesis: assumptions, challenges, potential -- Technical considerations.ÂÂ
As indicated by its title, this monograph deals chiefly with morphologically recognizable deviations from the normal anatomical condition of the human CNS. The AD-associated pathology is illustrated from its beginnings (sometimes even in childhood) to its final form, which is reached late in life. The AD process commences much earlier than the clinically recognizable phase of the disorder, and its timeline includes an extended preclinical phase. The further the pendulum swings away from the symptomatic final stages towards the early pathology, the more obvious the lesions become, although from a standpoint of severity they are more unremarkable and thus frequently overlooked during routine neuropathological assessment. For this reason, the authors deal with the hallmark lesions in the early phases of the AD process in considerable detail.
9783319126791
10.1007/978-3-319-12679-1 doi
Geriatría
Patología
Neurociencias
RC523 / 2015 EB