Lipid Nanoparticles : Production, Characterization and Stability
Shah, Rohan.
Lipid Nanoparticles : Production, Characterization and Stability by Rohan Shah, Daniel Eldridge, Enzo Palombo, Ian Harding. - Cham, Switzerland Springer 2015 - 1 recurso en línea (IX, 97 páginas) 30 ilustraciones, 18 ilustraciones en color - SpringerBriefs in Pharmaceutical Science & Drug Development 1864-8118 .
Introduction -- Composition and structure -- Production techniques -- Characterization -- Physicochemical stability.
What are lipid nanoparticles?Âȯw are they structured?Âȯw are they formed? What techniques are best to characterize them?Âȯw great is their potential as drug delivery systems?These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear andÂerstandableÂerstanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. AÂprehensive description of current understanding of synthesis, characterization, stability optimization and drug incorporation of solid lipid nanoparticles is provided. Nanoparticles have attracted great interest over the past few decades with almost exponential growth in their research and application. Their small particle size and subsequent high surface area make them ideal in many uses, but particularly as drug carrier systems.Ânoparticles made from lipids are especially attractive because of their enhanced biocompatibility imparted by the lipid. TheÂk provides a detailed description of the types of lipid nanoparticles available (e.g. SLN, NLC, LDC, PLN) and how they range from imperfect crystalline to amorphous in structure.Ârrent thoughts on where drugs are situated (e.g. in the core, or at the interface) and how this can be manipulated are discussed.The many techniques for production, including the authorâ€wn variant of microwave heating, are fully discussed.Âhniques for measuring arguably the most important characteristics of particle size and polydispersity are discussed, along with techniques to measure crystallinity, shape and drug capacity.Ânally, a full chapter on techniques for measuring stability, both in the absence and presence of drugs, is discussed, along with suggestions on how to optimize that stability. ThisÂk appealsÂstudents of colloid science, practitioners of research into drug delivery and academics alike.
9783319107110
10.1007/978-3-319-10711-0 doi
Tecnología farmacéutica
Biotecnología
Lípidos
RS201.N35 / 2015 EB
Lipid Nanoparticles : Production, Characterization and Stability by Rohan Shah, Daniel Eldridge, Enzo Palombo, Ian Harding. - Cham, Switzerland Springer 2015 - 1 recurso en línea (IX, 97 páginas) 30 ilustraciones, 18 ilustraciones en color - SpringerBriefs in Pharmaceutical Science & Drug Development 1864-8118 .
Introduction -- Composition and structure -- Production techniques -- Characterization -- Physicochemical stability.
What are lipid nanoparticles?Âȯw are they structured?Âȯw are they formed? What techniques are best to characterize them?Âȯw great is their potential as drug delivery systems?These questions and more are answered in this comprehensive and highly readable work on lipid nanoparticles. This work sets out to provide the reader with a clear andÂerstandableÂerstanding of the current practices in formulation, characterization and drug delivery of lipid nanoparticles. AÂprehensive description of current understanding of synthesis, characterization, stability optimization and drug incorporation of solid lipid nanoparticles is provided. Nanoparticles have attracted great interest over the past few decades with almost exponential growth in their research and application. Their small particle size and subsequent high surface area make them ideal in many uses, but particularly as drug carrier systems.Ânoparticles made from lipids are especially attractive because of their enhanced biocompatibility imparted by the lipid. TheÂk provides a detailed description of the types of lipid nanoparticles available (e.g. SLN, NLC, LDC, PLN) and how they range from imperfect crystalline to amorphous in structure.Ârrent thoughts on where drugs are situated (e.g. in the core, or at the interface) and how this can be manipulated are discussed.The many techniques for production, including the authorâ€wn variant of microwave heating, are fully discussed.Âhniques for measuring arguably the most important characteristics of particle size and polydispersity are discussed, along with techniques to measure crystallinity, shape and drug capacity.Ânally, a full chapter on techniques for measuring stability, both in the absence and presence of drugs, is discussed, along with suggestions on how to optimize that stability. ThisÂk appealsÂstudents of colloid science, practitioners of research into drug delivery and academics alike.
9783319107110
10.1007/978-3-319-10711-0 doi
Tecnología farmacéutica
Biotecnología
Lípidos
RS201.N35 / 2015 EB