Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases

Natural Compounds as Therapeutic Agents for Amyloidogenic Diseases edited by Neville Vassallo. - Cham, Switzerland Springer 2015 - 1 recurso en línea (VII, 163 páginas) 41 ilustraciones, 26 ilustraciones en color - Advances in Experimental Medicine and Biology 863 0065-2598 .

Olive Oil Phenols as Promising Multi-targeting Agents against Alzheimer's disease -- Alzheimerâ€isease, Drosophila melanogaster and Polyphenols -- Biflavonoids as Potential Small Molecule Therapeutics for Alzheimerâ€isease -- Natural Phenolic Compounds as Therapeutic and Preventive Agents for Cerebral Amyloidosis.-Âain Food for Alzheimer-free Ageing: Focus on Herbal Medicines -- Tea Polyphenols in Parkinsonâ€isease -- The Effect of (-)-Epigallo-catechin-(3)-gallate on Amyloidogenic Proteins Suggests a Common Mechanism.

This edited volume concerns a group of devastating neurological disorders that share a common pathological mechanism, namely the aggregation and deposition of insoluble, proteinaceous lesions, termed â€ãmyloidâ€xamples of cerebral amyloid disorders include common neurodegenerative diseases like Alzheimerâ€isease-related dementia and Parkinsonâ€isease, as well as other less prevalent conditions like Huntingtonâ€isease, cerebral amyloid angiopathy and the transmissible prion disorders. A disease-modifying therapeutic agent is still lacking for all these diseases, and there are no approved therapies that target amyloid formation directly. Nevertheless, a large and complex group of natural aromatic compounds known as polyphenols are rapidly emerging as potentially potent anti-amyloidogenic agents. This book collectively presents a considerable body of experimental and epidemiological evidence from peer-reviewed scientific publications that support a role for natural compounds and herbal extracts in the chemoprevention and therapy of amyloidogenic disorders. Each contribution is written by scientific experts in the relevant field; chapters are devoted to Mediterranean diet and olive oil phenols, traditional Chinese medicine, herbal extracts, polyphenols (with a particular emphasis on epigallocatechin-3-gallate) and bi-flavonoids, amongst others. The topic of this book is relevant to a wide audience, from academia and university students in the biological and chemical sciences, to physicians and allied health professionals, as well as people working in the nutraceutical industry.

9783319183657

10.1007/978-3-319-18365-7 doi


Farmacia
Neuroquímica
Nutrición

RC632.A5 / N388 2015