Autoimmune Liver Diseases : Perspectives from Japan
Autoimmune Liver Diseases : Perspectives from Japan
edited by Hiromasa Ohira.
- Tokyo Springer 2014
- 1 recurso en línea (VIII, 305 páginas) 70 ilustraciones, 44 ilustraciones en color
Preface -- Part IÂtoimmune Hepatitis.-Âhogenesis of Autoimmune Hepatitis-. 2Âimal Models of Autoimmune Hepatitis -- 3Âidemiology and Natural History in Japan -- 4Âstological Findings of Autoimmune Hepatitis -- 5Âagnosis of Autoimmune Hepatitis -- 6Âute Presentation of Autoimmune Hepatitis -- 7Âatment of Autoimmune Hepatitis -- 8Ânagement Strategies for Autoimmune Hepatitis Treatment Non-Responders -- 9Âiatric Autoimmune Hepatitis -- 10Ânalcoholic Steatohepatitis -Autoimmune Hepatitis Overlap -- 11ÂG4-Related Autoimmune Hepatitis -- Part II Primary Biliary Cirrhosis -- 12Â Onset Mechanism of Primary Biliary Cirrhosis -- 13Ânetic Factors in Pathogenesis of Primary Biliary Cirrhosis -- 14Âimal Models of Primary Biliary Cirrhosis -- 15Âidemiology and Natural History in Japan -- 16Âw Histological Staging and Grading System for Primary Biliary Cirrhosis -- 17Âtoantibodies in Primary Biliary Cirrhosis -- 18Âagnosis and UDCA Treatment of Primary Biliary Cirrhosis -- 19Âzafibrate Treatment of Primary Biliary Cirrhosis -- 20Ânagement the Patients with Feature of Autoimmune Hepatitis -- 21Âver Transplantation for Primary Biliary CirrhosisÂ.
Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC. AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease. Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.
9784431547891
10.1007/978-4-431-54789-1 doi
Medicina clínica
Hepatología
RC845 / .A986 2014
Preface -- Part IÂtoimmune Hepatitis.-Âhogenesis of Autoimmune Hepatitis-. 2Âimal Models of Autoimmune Hepatitis -- 3Âidemiology and Natural History in Japan -- 4Âstological Findings of Autoimmune Hepatitis -- 5Âagnosis of Autoimmune Hepatitis -- 6Âute Presentation of Autoimmune Hepatitis -- 7Âatment of Autoimmune Hepatitis -- 8Ânagement Strategies for Autoimmune Hepatitis Treatment Non-Responders -- 9Âiatric Autoimmune Hepatitis -- 10Ânalcoholic Steatohepatitis -Autoimmune Hepatitis Overlap -- 11ÂG4-Related Autoimmune Hepatitis -- Part II Primary Biliary Cirrhosis -- 12Â Onset Mechanism of Primary Biliary Cirrhosis -- 13Ânetic Factors in Pathogenesis of Primary Biliary Cirrhosis -- 14Âimal Models of Primary Biliary Cirrhosis -- 15Âidemiology and Natural History in Japan -- 16Âw Histological Staging and Grading System for Primary Biliary Cirrhosis -- 17Âtoantibodies in Primary Biliary Cirrhosis -- 18Âagnosis and UDCA Treatment of Primary Biliary Cirrhosis -- 19Âzafibrate Treatment of Primary Biliary Cirrhosis -- 20Ânagement the Patients with Feature of Autoimmune Hepatitis -- 21Âver Transplantation for Primary Biliary CirrhosisÂ.
Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC. AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease. Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.
9784431547891
10.1007/978-4-431-54789-1 doi
Medicina clínica
Hepatología
RC845 / .A986 2014