Gene prioritization : rationale, methodologies and algorithms
Masoudi-Nejad, Ali
Gene prioritization : rationale, methodologies and algorithms by Ali Masoudi-Nejad, Alireza Meshkin - Cham Springer International Publishing 2014 - 1 recurso en línea (XII, 66 p.) 30 ilustraciones, 21 ilustraciones en color - SpringerBriefs in Systems Biology 2193-4746 .
Gene Prioritization Concepts -- Gene Prioritization Rationale -- Evaluations Methods for Gene Prioritization -- Gene Prioritization algorithms -- Successes -- Non-networked-based apoproaches -- Network-based approaches -- Conclusions
Identifying causal genes underlying susceptibility to human disease is a problem of primary importance in the post-genomic era and in current biomedical research. Recently, there has been a paradigm shift of such gene-discovery efforts from rare, monogenic conditions to common 2oligogenic3 or 2multifactorial3 conditions such as asthma, diabetes, cancers and neurological disorders. These conditions are referred to as multifactorial because, susceptibility to these diseases is attributed to the combinatorial effects of genetic variation at a number of different genes and their interaction with relevant environmental exposures. The goal of this book is to introduce gene prioritization aspects and the candidate gene prioritization algorithms to give readers a comprehensive view on the subject
9783319046877
10.1007/978-3-319-04687-7 doi
Genética médica
Etiología médica
RB155 / .M37 2014 EB
611.01816 599.935
Gene prioritization : rationale, methodologies and algorithms by Ali Masoudi-Nejad, Alireza Meshkin - Cham Springer International Publishing 2014 - 1 recurso en línea (XII, 66 p.) 30 ilustraciones, 21 ilustraciones en color - SpringerBriefs in Systems Biology 2193-4746 .
Gene Prioritization Concepts -- Gene Prioritization Rationale -- Evaluations Methods for Gene Prioritization -- Gene Prioritization algorithms -- Successes -- Non-networked-based apoproaches -- Network-based approaches -- Conclusions
Identifying causal genes underlying susceptibility to human disease is a problem of primary importance in the post-genomic era and in current biomedical research. Recently, there has been a paradigm shift of such gene-discovery efforts from rare, monogenic conditions to common 2oligogenic3 or 2multifactorial3 conditions such as asthma, diabetes, cancers and neurological disorders. These conditions are referred to as multifactorial because, susceptibility to these diseases is attributed to the combinatorial effects of genetic variation at a number of different genes and their interaction with relevant environmental exposures. The goal of this book is to introduce gene prioritization aspects and the candidate gene prioritization algorithms to give readers a comprehensive view on the subject
9783319046877
10.1007/978-3-319-04687-7 doi
Genética médica
Etiología médica
RB155 / .M37 2014 EB
611.01816 599.935