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Iron acquisition by the genus mycobacterium : history, mechanisms, role of siderocalin, anti-tuberculosis drug development edited by B. Rowe Byers - Heidelberg Springer International Publishing 2013 - 1 recurso en línea (V, 92 p.) 39 ilustraciones, 9 ilustraciones en color - SpringerBriefs in Molecular Science 2191-5407 .

A History of Iron Metabolism in the Mycobacteria -- Mycobacterial Iron Uptake Mechanisms -- Siderocalin Combats Mycobacterial Infections -- Design of Anti-TB Drugs Using the Iron Uptake Platform

Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates

ISBN: 9783319003030

Standard No.: 10.1007/978-3-319-00303-0 doi

Subjects--Topical Terms:
Micobacterias
Microbiología

LC Class. No.: QR82.M8 / I76 2013 EB

Dewey Class. No.: 579