Gamma-Glutamyl Transpeptidases : structure and function
Castellano, Immacolata
Gamma-Glutamyl Transpeptidases : structure and function by Immacolata Castellano, Antonello Merlino - Basel Springer International Publishing 2013 - 1 recurso en línea (VIII, 57 p.) 28 ilustraciones, 18 ilustraciones en color - SpringerBriefs in Biochemistry and Molecular Biology 2211-9353 .
1 Introduction -- 2 Occurrence, genes and gene expression -- 3 Structure and function of -GTs -- 4 Autoprocessing and reaction mechanism of -GTs -- 5 -GT in bioclinical -- 6 -GTs: biotechnological and biomedical applications -- 7 Conclusions -- References
Gamma-Glutamyl Transpeptidases (-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the -glutamyl amide bond of glutathione to liberate cysteinylglycine. The released -glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). -GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinsons disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book coverscurrent knowledge about the structure-function relationship of -GTs andgives information aboutapplications of -GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine
9783034806824
10.1007/978-3-0348-0682-4 doi
Enzimas
Ingeniería bioquímica
QP601 / .C37 2013 EB
572.6
Gamma-Glutamyl Transpeptidases : structure and function by Immacolata Castellano, Antonello Merlino - Basel Springer International Publishing 2013 - 1 recurso en línea (VIII, 57 p.) 28 ilustraciones, 18 ilustraciones en color - SpringerBriefs in Biochemistry and Molecular Biology 2211-9353 .
1 Introduction -- 2 Occurrence, genes and gene expression -- 3 Structure and function of -GTs -- 4 Autoprocessing and reaction mechanism of -GTs -- 5 -GT in bioclinical -- 6 -GTs: biotechnological and biomedical applications -- 7 Conclusions -- References
Gamma-Glutamyl Transpeptidases (-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the -glutamyl amide bond of glutathione to liberate cysteinylglycine. The released -glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). -GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinsons disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book coverscurrent knowledge about the structure-function relationship of -GTs andgives information aboutapplications of -GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine
9783034806824
10.1007/978-3-0348-0682-4 doi
Enzimas
Ingeniería bioquímica
QP601 / .C37 2013 EB
572.6