Advancing Gene Fusion Detection Towards Personalized Cancer Nanodiagnostics

Koo, Kevin M.

Advancing Gene Fusion Detection Towards Personalized Cancer Nanodiagnostics by Kevin M. Koo. - 1st ed. 2019. - 1 recurso en línea (XIII, 102 páginas) - Springer Theses Recognizing Outstanding Ph.D. Research 2190-5053 Biomedical and Life Sciences (Springer-11642) .

Unifying Next-Generation Biomarkers and Nanodiagnostic Platforms for Precision Prostate Cancer (PCa) Management -- Colorimetric Gene Fusion Diagnostics for Visual Binary Readout -- Label -Free Surface-Enhanced Raman Scattering Detection System for Clinical Biomarker Targets -- Amplification-Free Electrochemical RNA Biomarker Sensing -- Simultaneous Analysis of Multiple Biomarkers via High-Throughput Parallel Profiling.

This book presents a unique concept of merging nanotechnology and novel urinary biomarkers for accurate early prostate cancer detection, discussing an entire progressive pipeline of innovative new strategies in biosensor development, from a simple colorimetric system to a complex system for simultaneous multiple biomarker sensing. For newcomers to the field of nucleic acid biosensing, it also describes various isothermal amplification and amplification-free strategies, which are currently the main research areas. Lastly, the book introduces and demonstrates the notion of clinical nanobiosensor validation toward clinical translation: the ultimate aim of researchers in the biosensor field. This book is a valuable reference resource learners seeking inspiration for cancer biosensor development.

9783030310004

10.1007/978-3-030-31000-4 doi


Próstata--Cáncer
Marcadores biológicos

RC899 / 2019 EB